• Clonality :
• Monoclonal

• Description :
• Thymidylate synthase converts deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP), which is essential for DNA biosynthesis. Thymidylate synthase is also a critical target for the fluoropyrimidines, an important group of anti-neoplastic drugs that are widely used in the treatment of solid tumors. Both 5-FU and fluorodeoxyuridine are converted in tumor cells to FdUMP which inactivates thymidylate synthase by formation of a ternary covalent complex in the presence of the folate cofactor 5,10-methylenetetrahydrofolate. Expression of thymidylate synthase protein is associated with response to 5-fluorouracil (5-FU) in human colorectal, gastric, head and neck, and breast carcinomas.

• Formulation :
• 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide

• Host :
• Mouse

• Immunogen Region :
• A recombinant human protein from within amino acids 60-174 was used as the immunogen for this Thymidylate synthase antibody.

• Isotype :
• IgG2c,kappa

• Predicted Reactivity :
• Human

• Reactivity :
• Human

• Recombinant :
• No

• Subcellular Location :
• Cytoplasmic, nuclear

• Antigen :
• Thymidylate Synthase

• Gene Id :
• 7298

• Clone No :
• TYSY9-2

• Concentration :
• 0.2 mg/ml

• Format :
• Purified

• Purification :
• Protein G purified monoclonal antibody

• Storage :
• Store the Thymidylate synthase antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).

• Product Manual :
• <a href="http://www.nsjbio.com/tds-pdf/thymidylate-synthase-antibody-tysy9-2-v7622" target="_blank">Data Sheet</a>