• Clonality :
• Monoclonal

• Description :
• MSH6 is a component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS alpha, which binds to DNA mismatches thereby initiating DNA repair. When bound, MutS alpha bends the DNA helix and shields approximately 20 base pairs, and recognizes single base mismatches and dinucleotide insertion-deletion loops (IDL) in the DNA. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. (UniProt)

• Formulation :
• 0.2 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide

• Host :
• Mouse

• Immunogen Region :
• A recombinant human MSH6 protein fragment within amino acids 374-540 was used as the immunogen for the MSH6 antibody.

• Isotype :
• IgG2b,kappa

• Predicted Reactivity :
• Human

• Reactivity :
• Human

• Recombinant :
• No

• Subcellular Location :
• Nucleus

• Antigen :
• MSH6

• Uniprot :
• P52701

• Clone No :
• MST6-2

• Concentration :
• 0.2 mg/ml

• Format :
• Purified

• Purification :
• Protein G affinity chromatography

• Storage :
• Store the MSH6 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).

• Product Manual :
• <a href="http://www.nsjbio.com/tds-pdf/msh6-antibody-mst6-2-v7592" target="_blank">Data Sheet</a>