• Clonality :
• Monoclonal

• Description :
• Spectrins are principle components of a cell's membrane-cytoskeleton and are composed of two alpha and two beta spectrin subunits. The protein encoded by this gene (SPTBN2), is called spectrin beta non-erythrocytic 2 or beta-III spectrin. It is related to, but distinct from, the beta-II spectrin gene which is also known as spectrin beta non-erythrocytic 1 (SPTBN1). SPTBN2 regulates the glutamate signaling pathway by stabilizing the glutamate transporter EAAT4 at the surface of the plasma membrane. Mutations in this gene cause a form of spinocerebellar ataxia, SCA5, that is characterized by neurodegeneration, progressive locomotor incoordination, dysarthria, and uncoordinated eye movements. (RefSeq)

• Formulation :
• 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide

• Host :
• Rabbit

• Immunogen Region :
• Amino acids 356-475 from the human protein were used as the immunogen for this recombinant SPTBN2 antibody.

• Isotype :
• IgG,kappa

• Predicted Reactivity :
• Human

• Reactivity :
• Human

• Recombinant :
• Yes

• Subcellular Location :
• Cell surface, cytoplasm

• Antigen :
• SPTBN2

• Uniprot :
• O15020

• Clone No :
• SCNB3-2R

• Concentration :
• 0.2 mg/ml

• Format :
• Purified

• Purification :
• Protein A affinity chromatography

• Storage :
• Store the recombinant SPTBN2 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).

• Product Manual :
• <a href="http://www.nsjbio.com/tds-pdf/recombinant-sptbn2-antibody-scnb3-2r-v7447" target="_blank">Data Sheet</a>