• Clonality :
• Monoclonal

• Description :
• Tumor Necrosis Factor Alpha (TNF alpha) is a cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation. Impairs regulatory T-cells (Treg) function in individuals with rheumatoid arthritis via FOXP3 dephosphorylation. Upregulates the expression of protein phosphatase 1 (PP1), which dephosphorylates the key 'Ser-418' residue of FOXP3, thereby inactivating FOXP3 and rendering Treg cells functionally defective. Key mediator of cell death in the anticancer action of BCG-stimulated neutrophils in combination with DIABLO/SMAC mimetic in the RT4v6 bladder cancer cell line. (UniProt)

• Formulation :
• 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide

• Host :
• Mouse

• Immunogen Region :
• Full length human recombinant protein was used as the immunogen for the TNF alpha antibody.

• Isotype :
• IgM,kappa

• Predicted Reactivity :
• Human, Rat

• Reactivity :
• Human, Rat

• Recombinant :
• No

• Subcellular Location :
• Cytoplasmic and extracellular (secreted)

• Antigen :
• TNF alpha

• Uniprot :
• P01375

• Clone No :
• TMDa1-1

• Concentration :
• 0.2 mg/ml

• Format :
• Purified

• Purification :
• PEG precipitation

• Storage :
• Store the TNF alpha antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).

• Product Manual :
• <a href="http://www.nsjbio.com/tds-pdf/tnf-alpha-antibody-tmda1-1-v7163" target="_blank">Data Sheet</a>