• Clonality :
• Monoclonal

• Description :
• Cyclin E belongs to the highly conserved cyclin family, whose members exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. Cyclins function as regulators of CDK kinases. Cyclin E forms a complex with and functions as a regulatory subunit of CDK2, whose activity is required for cell cycle G1/S transition. Cyclin E accumulates at the G1-S phase boundary and is degraded as cells progress through S phase. Cyclin E overexpression has been observed in many tumors, which results in chromosome instability, and thus may contribute to tumorigenesis.

• Formulation :
• 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide

• Host :
• Mouse

• Immunogen Region :
• Recombinant human partial protein (within amino acids 10-176) was used as the immunogen for the Cyclin E1 antibody.

• Isotype :
• IgG2b,kappa

• Predicted Reactivity :
• Human

• Reactivity :
• Human

• Recombinant :
• No

• Subcellular Location :
• Nuclear

• Antigen :
• Cyclin E1

• Uniprot :
• P24864

• Clone No :
• CCNE1/2460

• Concentration :
• 0.2 mg/ml

• Format :
• Purified

• Purification :
• Protein G affinity chromatography

• Storage :
• Store the Cyclin E1 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).

• Product Manual :
• <a href="http://www.nsjbio.com/tds-pdf/cyclin-e1-antibody-ccne1-2460-protein-microarray-validated-v3685" target="_blank">Data Sheet</a>