• Clonality :
• Monoclonal

• Description :
• Recognizes a cluster of proteins between 70-80kDa, identified as tyrosinase. Occasionally a minor band at 55kDa is also detected. This mAb shows no cross-reaction with MAGE-1 and tyrosinase-related protein 1, TRP-1/gp75. Tyrosinase is a copper-containing metalloglycoprotein that catalyzes several steps in the melanin pigment biosynthetic pathway; the hydroxylation of tyrosine to L-3,4-dihydroxy-phenylalanine (dopa), and the subsequent oxidation of dopa to dopaquinone. Mutations of the tyrosinase gene occur in various forms of albinism. Tyrosinase is one of the targets for cytotoxic T-cell recognition in melanoma patients. Staining of melanomas with this mAb shows tyrosinase in melanotic as well as amelanotic variants. This mAb is a useful marker for melanocytes and melanomas.

• Formulation :
• 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide

• Host :
• Rabbit

• Immunogen Region :
• Recombinant protein was used as the immunogen for this recombinant Tyrosinase antibody.

• Isotype :
• IgG,kappa

• Predicted Reactivity :
• Human

• Reactivity :
• Human

• Recombinant :
• Yes

• Subcellular Location :
• Cytoplasmic

• Antigen :
• Tyrosinase

• Uniprot :
• P14679

• Clone No :
• TYR/2024R

• Concentration :
• 0.2 mg/ml

• Format :
• Purified

• Purification :
• Protein A affinity chromatography

• Storage :
• Store the recombinant Tyrosinase antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).

• Product Manual :
• <a href="http://www.nsjbio.com/tds-pdf/recombinant-tyrosinase-antibody-tyr-2024r-v3657" target="_blank">Data Sheet</a>