• Alternative Names :
• Atypical kinase COQ8A, mitochondrial (EC 2.7.-.-) (Chaperone activity of bc1 complex-like) (Chaperone-ABC1-like) (Coenzyme Q protein 8A) (aarF domain-containing protein kinase 3), COQ8A, ADCK3 CABC1

• Categories :
• Primary Antibodies

• Clonality :
• polyclonal

• Description :
• Atypical kinase involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration . Its substrate specificity is unclear: either acts as protein kinase that phosphorylates other proteins in the CoQ complex to stabilize their interactions or acts as a small molecule kinase that phosphorylates a prenyl lipid in the ubiquinone biosynthesis pathway. Shows an unusual selectivity for binding ADP over ATP.

• Host :
• Rabbit

• Immunogen :
• Recombinant Human Atypical kinase ADCK3, mitochondrial protein (1-220AA)

• Involvement In Disease :
• Coenzyme Q10 deficiency, primary, 4 (COQ10D4)

• Isotype :
• IgG

• Raised In :
• Rabbit

• Reactivity :
• Human

• Regulatory :
• RUO

• Relevance :
• Atypical kinase involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration . Its substrate specificity is unclear: either acts as protein kinase that phosphorylates other proteins in the CoQ complex to stabilize their interactions or acts as a small molecule kinase that phosphorylates a prenyl lipid in the ubiquinone biosynthesis pathway. Shows an unusual selectivity for binding ADP over ATP.

• Species :
• Homo Sapiens (Human)

• Subcellular Location :
• Mitochondrion, Membrane, Single-pass membrane protein

• Antigen :
• COQ8A

• Uniprot :
• Q8NI60

• Gene Id :
• 56997

• Database Links :
• 
  

  HGNC:16812

  OMIM:606980

  KEGG:hsa:56997

  STRING:9606.ENSP00000355739

  UniGene:Hs.118241

• Function :
• Atypical kinase involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration

• Protein Families :
• Protein kinase superfamily, ADCK protein kinase family

• Research Area :
• Tags & Cell Markers

• Tissue Specificity :
• Widely expressed, with highest levels in adrenal gland, heart, pancreas, nasal mucosa, stomach, uterus and skeletal muscle.

• Weight :
• 42,537 Da

• Buffer :
• PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Form :
• Liquid

• Format :
• Liquid

• Purification :
• Antigen Affinity Purified

• Purity :
• Antigen Affinity Purified

• Storage :
• Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

• Storage Buffer :
• 
  
  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Datasheet :
• 

• ELISA Protocol :

• Immunohistochemistry (IHC) Protocol :