GCK Antibody

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GCK Antibody

Alternative Names Glucokinase (EC 2.7.1.2) (Hexokinase type IV) (HK IV) (Hexokinase-4) (HK4) (Hexokinase-D), GCK
Categories Primary Antibodies
Clonality polyclonal

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Description

Alternative Names :
Glucokinase (EC 2.7.1.2) (Hexokinase type IV) (HK IV) (Hexokinase-4) (HK4) (Hexokinase-D), GCK

Categories :
Primary Antibodies

Clonality :
polyclonal

Description :
Catalyzes the initial step in utilization of glucose by the beta-cell and liver at physiological glucose concentration. Glucokinase has a high Km for glucose, and so it is effective only when glucose is abundant. The role of GCK is to provide G6P for the synthesis of glycogen. Pancreatic glucokinase plays an important role in modulating insulin secretion. Hepatic glucokinase helps to facilitate the uptake and conversion of glucose by acting as an insulin-sensitive determinant of hepatic glucose usage.

Host :
Rabbit

Immunogen :
Recombinant Human Glucokinase protein (1-300AA)

Involvement In Disease :
Maturity-onset diabetes of the young 2 (MODY2); Familial hyperinsulinemic hypoglycemia 3 (HHF3); Diabetes mellitus, non-insulin-dependent (NIDDM); Diabetes mellitus, permanent neonatal (PNDM)

Isotype :
IgG

Raised In :
Rabbit

Reactivity :
Human

Regulatory :
RUO

Relevance :
Catalyzes the initial step in utilization of glucose by the beta-cell and liver at physiological glucose concentration. Glucokinase has a high Km for glucose, and so it is effective only when glucose is abundant. The role of GCK is to provide G6P for the synthesis of glycogen. Pancreatic glucokinase plays an important role in modulating insulin secretion. Hepatic glucokinase helps to facilitate the uptake and conversion of glucose by acting as an insulin-sensitive determinant of hepatic glucose usage.

Species :
Homo Sapiens (Human)

Subcellular Location :
Cytoplasm, Nucleus

Target

Uniprot :
P35557

Database Links :
HGNC:4195
OMIM:125851
KEGG:hsa:2645
STRING:9606.ENSP00000223366
UniGene:Hs.1270

Function :
Catalyzes the initial step in utilization of glucose by the beta-cell and liver at physiological glucose concentration. Glucokinase has a high Km for glucose, and so it is effective only when glucose is abundant. The role of GCK is to provide G6P for the synthesis of glycogen. Pancreatic glucokinase plays an important role in modulating insulin secretion. Hepatic glucokinase helps to facilitate the uptake and conversion of glucose by acting as an insulin-sensitive determinant of hepatic glucose usage.

Pathway :
Glucagon signaling pathway Insulin signaling pathway

Protein Families :
Hexokinase family

Research Area :
Signal Transduction

Tissue Specificity :
Isoform 1 is expressed in pancreas. Isoform 2 and isoform 3 is expressed in liver.

Property

Buffer :
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form :
Liquid

Format :
Liquid

Purification :
Antigen Affinity Purified

Purity :
Antigen Affinity Purified

Storage :
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Storage Buffer :
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Applications

Application

Description

Dilution

Dilution: ELISA, WB, IHC

Dilution: ELISA ; WB ; IHC, WB ; ELISA ; IHC

Dilution:

WB	1:200-1000
IHC	1:20-1:200

Dilution: ELISA, WB, IHC; Recommended dilution: WB:1:200-1:1000, IHC:1:20-1:200

Protocols

Datasheet :

ELISA Protocol :

Western Blotting(WB) Protocol :

Immunohistochemistry (IHC) Protocol :