• Alternative Names :
• 14-3-3 protein theta (14-3-3 protein T-cell) (14-3-3 protein tau) (Protein HS1), YWHAQ

• Categories :
• Primary Antibodies

• Clonality :
• polyclonal

• Description :
• Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1.

• Host :
• Rabbit

• Immunogen :
• Recombinant Human 14-3-3 protein theta protein (1-245AA)

• Isotype :
• IgG

• Raised In :
• Rabbit

• Reactivity :
• Human

• Regulatory :
• RUO

• Relevance :
• Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1.

• Species :
• Homo Sapiens (Human)

• Subcellular Location :
• Cytoplasm

• Uniprot :
• P27348

• Database Links :
• 
  

  HGNC:12854

  OMIM:609009

  KEGG:hsa:10971

  STRING:9606.ENSP00000238081

  UniGene:Hs.74405

• Function :
• Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1.

• Pathway :
• Hippo signaling pathway PI3K-Akt signaling pathway Cell cycle

• Protein Families :
• 14-3-3 family

• Research Area :
• Neuroscience

• Tissue Specificity :
• Abundantly expressed in brain, heart and pancreas, and at lower levels in kidney and placenta. Up-regulated in the lumbar spinal cord from patients with sporadic amyotrophic lateral sclerosis (ALS) compared with controls, with highest levels of expression

• Buffer :
• PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Form :
• Liquid

• Format :
• Liquid

• Purification :
• Antigen Affinity Purified

• Purity :
• Antigen Affinity Purified

• Storage :
• Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

• Storage Buffer :
• 
  
  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Datasheet :
• 

• ELISA Protocol :

• Immunohistochemistry (IHC) Protocol :