SOCS2 Antibody

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SOCS2 Antibody

Alternative Names Suppressor of cytokine signaling 2 (SOCS-2) (Cytokine-inducible SH2 protein 2) (CIS-2) (STAT-induced STAT inhibitor 2) (SSI-2), SOCS2, CIS2 SSI2...
Categories Primary Antibodies
Clonality polyclonal

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suppilerCUSABIO TECHONOLOGY LLC
merchant skuCSB-PA022389ESR2HU
item price299.00000
sale price299.00000
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suppilerCOHESION BIOSCIENCES
merchant skuCSB-PA022389ESR2HU
item price168.78000
sale price168.78000
quantityUnlimited
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Description

Description

Alternative Names :
Suppressor of cytokine signaling 2 (SOCS-2) (Cytokine-inducible SH2 protein 2) (CIS-2) (STAT-induced STAT inhibitor 2) (SSI-2), SOCS2, CIS2 SSI2 STATI2

Categories :
Primary Antibodies

Clonality :
polyclonal

Description :
SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS2 appears to be a negative regulator in the growth hormone/IGF1 signaling pathway. Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

Host :
Rabbit

Immunogen :
Recombinant Human Suppressor of cytokine signaling 2 protein (1-198AA)

Isotype :
IgG

Raised In :
Rabbit

Reactivity :
Human

Regulatory :
RUO

Relevance :
SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS2 appears to be a negative regulator in the growth hormone/IGF1 signaling pathway. Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

Species :
Homo Sapiens (Human)

Target

Target

Antigen :
SOCS2

Uniprot :
O14508

Database Links :
HGNC:19382
OMIM:605117
KEGG:hsa:8835
STRING:9606.ENSP00000339428
UniGene:Hs.485572

Function :
SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS2 appears to be a negative regulator in the growth hormone/IGF1 signaling pathway. Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

Pathway :
Jak-STAT signaling pathway Insulin signaling pathway

Research Area :
Immunology

Tissue Specificity :
High expression in heart, placenta, lung, kidney and prostate.

Property

Property

Buffer :
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form :
Liquid

Format :
Liquid

Purification :
Antigen Affinity Purified

Purity :
Antigen Affinity Purified

Storage :
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Storage Buffer :
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Applications

Applications

Application

Description

Dilution

Dilution: ELISA, WB, IHC

Dilution: ELISA ; WB ; IHC, WB ; ELISA ; IHC

Dilution:

WB	1:200-1000
IHC	1:20-1:200

Dilution: ELISA, WB, IHC; Recommended dilution: WB:1:200-1:1000, IHC:1:20-1:200

Protocols

Protocols

Datasheet :

ELISA Protocol :

Western Blotting(WB) Protocol :

Immunohistochemistry (IHC) Protocol :

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