• Alternative Names :
• Methyl-CpG-binding protein 2 (MeCp-2 protein) (MeCp2), MECP2

• Categories :
• Primary Antibodies

• Clonality :
• polyclonal

• Description :
• Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Mediates transcriptional repression through interaction with histone deacetylase and the corepressor SIN3A. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC) (By similarity).

• Host :
• Rabbit

• Immunogen :
• Recombinant Human Methyl-CpG-binding protein 2 protein (1-280AA)

• Involvement In Disease :
• Angelman syndrome (AS); Mental retardation, X-linked, syndromic, 13 (MRXS13); Rett syndrome (RTT); Autism, X-linked 3 (AUTSX3); Encephalopathy, neonatal severe, due to MECP2 mutations (ENS-MECP2); Mental retardation, X-linked, syndromic, Lubs type (MRXSL)

• Isotype :
• IgG

• Raised In :
• Rabbit

• Reactivity :
• Human

• Regulatory :
• RUO

• Relevance :
• Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Mediates transcriptional repression through interaction with histone deacetylase and the corepressor SIN3A. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC) (By similarity).

• Species :
• Homo Sapiens (Human)

• Subcellular Location :
• Nucleus

• Antigen :
• MeCP2

• Uniprot :
• P51608

• Database Links :
• 
  

  HGNC:6990

  OMIM:105830

  KEGG:hsa:4204

  STRING:9606.ENSP00000395535

  UniGene:Hs.200716

• Function :
• Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Mediates transcriptional repression through interaction with histone deacetylase and the corepressor SIN3A. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC).

• Research Area :
• Epigenetics and Nuclear Signaling

• Tissue Specificity :
• Present in all adult somatic tissues tested.

• Buffer :
• PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Form :
• Liquid

• Format :
• Liquid

• Purification :
• Antigen Affinity Purified

• Purity :
• Antigen Affinity Purified

• Storage :
• Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

• Storage Buffer :
• 
  
  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Datasheet :
• 

• ELISA Protocol :

• Immunohistochemistry (IHC) Protocol :