• Alternative Names :
• T-cell surface glycoprotein CD3 delta chain (T-cell receptor T3 delta chain) (CD antigen CD3d), CD3D, T3D

• Categories :
• Primary Antibodies

• Clonality :
• polyclonal

• Description :
• The CD3 complex mediates signal transduction.

• Host :
• Rabbit

• Immunogen :
• Recombinant Human T-cell surface glycoprotein CD3 delta chain protein (22-105AA)

• Involvement In Disease :
• Immunodeficiency 19 (IMD19)

• Isotype :
• IgG

• Raised In :
• Rabbit

• Reactivity :
• Human

• Regulatory :
• RUO

• Relevance :
• The CD3 complex mediates signal transduction.

• Species :
• Homo Sapiens (Human)

• Subcellular Location :
• Cell membrane, Single-pass type I membrane protein

• Antigen :
• CD3D

• Uniprot :
• P04234

• Database Links :
• 
  

  HGNC:1673

  OMIM:186790

  KEGG:hsa:915

  STRING:9606.ENSP00000300692

  UniGene:Hs.504048

• Function :
• Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways

• Pathway :
• Hematopoietic cell lineage T cell receptor signaling pathway Th1 and Th2 cell differentiation Th17 cell differentiation

• Research Area :
• Immunology

• Tissue Specificity :
• CD3D is mostly present on T-lymphocytes with its TCR-CD3 partners. Present also in fetal NK-cells.

• Buffer :
• PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Form :
• Liquid

• Format :
• Liquid

• Purification :
• Antigen Affinity Purified

• Purity :
• Antigen Affinity Purified

• Storage :
• Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

• Storage Buffer :
• 
  
  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Datasheet :
• 

• ELISA Protocol :

• Immunohistochemistry (IHC) Protocol :