• Alternative Names :
• Activin receptor type-2A (EC 2.7.11.30) (Activin receptor type IIA) (ACTR-IIA) (ACTRIIA), ACVR2A, ACVR2

• Categories :
• Primary Antibodies

• Clonality :
• polyclonal

• Description :
• On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A.

• Host :
• Rabbit

• Immunogen :
• Recombinant Human Activin receptor type-2A protein (20-140AA)

• Isotype :
• IgG

• Raised In :
• Rabbit

• Reactivity :
• Human, Mouse

• Regulatory :
• RUO

• Relevance :
• On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A.

• Species :
• Homo Sapiens (Human)

• Subcellular Location :
• Membrane, Single-pass type I membrane protein

• Antigen :
• ACVR2A

• Uniprot :
• P27037

• Gene Id :
• 92

• Database Links :
• 
  

  HGNC:173

  OMIM:102581

  KEGG:hsa:92

  STRING:9606.ENSP00000241416

  UniGene:Hs.470174

• Function :
• On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A. Mediates induction of adipogenesis by GDF6 (By similarity).

• Pathway :
• TGF-beta signaling pathway Signaling pathways regulating pluripotency of stem cells

• Protein Families :
• Protein kinase superfamily, TKL Ser/Thr protein kinase family, TGFB receptor subfamily

• Research Area :
• Signal Transduction

• Weight :
• 45,713 Da

• Buffer :
• PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Form :
• Liquid

• Format :
• Liquid

• Purification :
• Antigen Affinity purified

• Purity :
• Antigen Affinity purified

• Storage :
• Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

• Storage Buffer :
• 
  
  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Datasheet :
• 

• ELISA Protocol :

• Western Blotting(WB) Protocol :

• Immunohistochemistry (IHC) Protocol :