• Alternative Names :
• Histone chaperone ASF1A (Anti-silencing function protein 1 homolog A) (hAsf1) (hAsf1a) (CCG1-interacting factor A) (CIA) (hCIA), ASF1A

• Categories :
• Primary Antibodies

• Clonality :
• polyclonal

• Description :
• Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly. Cooperates with chromatin assembly factor 1 (CAF-1) to promote replication-dependent chromatin assembly and with HIRA to promote replication-independent chromatin assembly. Required for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associated cell cycle exit.

• Host :
• Rabbit

• Immunogen :
• Recombinant Human Histone chaperone ASF1A protein (1-204AA)

• Isotype :
• IgG

• Raised In :
• Rabbit

• Reactivity :
• Human

• Regulatory :
• RUO

• Relevance :
• Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly. Cooperates with chromatin assembly factor 1 (CAF-1) to promote replication-dependent chromatin assembly and with HIRA to promote replication-independent chromatin assembly. Required for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associated cell cycle exit.

• Species :
• Homo Sapiens (Human)

• Subcellular Location :
• Nucleus

• Antigen :
• Asf1a

• Uniprot :
• Q9Y294

• Gene Id :
• 25842

• Database Links :
• 
  

  HGNC:20995

  OMIM:609189

  KEGG:hsa:25842

  STRING:9606.ENSP00000229595

  UniGene:Hs.292316

• Function :
• Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly. Cooperates with chromatin assembly factor 1 (CAF-1) to promote replication-dependent chromatin assembly and with HIRA to promote replication-independent chromatin assembly. Required for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associated cell cycle exit.

• Protein Families :
• ASF1 family

• Research Area :
• Epigenetics and Nuclear Signaling

• Tissue Specificity :
• Ubiquitously expressed.

• Weight :
• 22,969 Da

• Buffer :
• PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Form :
• Liquid

• Format :
• Liquid

• Purification :
• Antigen Affinity Purified

• Purity :
• Antigen Affinity Purified

• Storage :
• Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

• Storage Buffer :
• 
  
  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Datasheet :
• 

• ELISA Protocol :

• Western Blotting(WB) Protocol :

• Immunohistochemistry (IHC) Protocol :