• Alternative Names :
• Myc box-dependent-interacting protein 1 (Amphiphysin II) (Amphiphysin-like protein) (Box-dependent myc-interacting protein 1) (Bridging integrator 1), BIN1, AMPHL

• Categories :
• Primary Antibodies

• Clonality :
• polyclonal

• Description :
• May be involved in regulation of synaptic vesicle endocytosis. May act as a tumor suppressor and inhibits malignant cell transformation.

• Host :
• Rabbit

• Immunogen :
• Recombinant Human Myc box-dependent-interacting protein 1 protein (414-593AA)

• Involvement In Disease :
• Myopathy, centronuclear, 2 (CNM2)

• Isotype :
• IgG

• Raised In :
• Rabbit

• Reactivity :
• Human

• Regulatory :
• RUO

• Relevance :
• May be involved in regulation of synaptic vesicle endocytosis. May act as a tumor suppressor and inhibits malignant cell transformation.

• Species :
• Homo Sapiens (Human)

• Subcellular Location :
• Isoform BIN1: Nucleus, SUBCELLULAR LOCATION: Isoform IIA: Cytoplasm

• Uniprot :
• O00499

• Gene Id :
• 274

• Database Links :
• 
  

  HGNC:1052

  OMIM:255200

  KEGG:hsa:274

  STRING:9606.ENSP00000316779

  UniGene:Hs.193163

• Function :
• May be involved in regulation of synaptic vesicle endocytosis. May act as a tumor suppressor and inhibits malignant cell transformation.

• Pathway :
• Fc gamma R-mediated phagocytosis Endocytosis

• Research Area :
• Cell Biology

• Tissue Specificity :
• Ubiquitous. Highest expression in the brain and muscle. Isoform IIA is expressed only in the brain where it is concentrated in axon initial segments and nodes of Ranvier. Isoform BIN1 is widely expressed with highest expression in skeletal muscle.

• Weight :
• 54,948 Da

• Buffer :
• PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Form :
• Liquid

• Format :
• Liquid

• Purification :
• Antigen Affinity Purified

• Purity :
• Antigen Affinity Purified

• Storage :
• Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

• Storage Buffer :
• 
  
  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Datasheet :
• 

• ELISA Protocol :

• Immunohistochemistry (IHC) Protocol :