• Alternative Names :
• Glycine amidinotransferase, mitochondrial (EC 2.1.4.1) (L-arginine:glycine amidinotransferase) (Transamidinase), GATM, AGAT

• Categories :
• Primary Antibodies

• Clonality :
• polyclonal

• Description :
• Catalyzes the biosynthesis of guanidinoacetate, the immediate precursor of creatine. Creatine plays a vital role in energy metabolism in muscle tissues. May play a role in embryonic and central nervous system development. May be involved in the response to heart failure by elevating local creatine synthesis.

• Host :
• Rabbit

• Immunogen :
• Recombinant Human Glycine amidinotransferase, mitochondrial protein (124-423AA)

• Involvement In Disease :
• Cerebral creatine deficiency syndrome 3 (CCDS3)

• Isotype :
• IgG

• Raised In :
• Rabbit

• Reactivity :
• Human, Mouse

• Regulatory :
• RUO

• Relevance :
• Catalyzes the biosynthesis of guanidinoacetate, the immediate precursor of creatine. Creatine plays a vital role in energy metabolism in muscle tissues. May play a role in embryonic and central nervous system development. May be involved in the response to heart failure by elevating local creatine synthesis.

• Species :
• Homo Sapiens (Human)

• Subcellular Location :
• Isoform 1: Mitochondrion inner membrane, Peripheral membrane protein, Intermembrane side

• Antigen :
• GATM

• Uniprot :
• P50440

• Gene Id :
• 2628

• Database Links :
• 
  

  HGNC:4175

  OMIM:602360

  KEGG:hsa:2628

  STRING:9606.ENSP00000379895

  UniGene:Hs.560354

• Function :
• Catalyzes the biosynthesis of guanidinoacetate, the immediate precursor of creatine. Creatine plays a vital role in energy metabolism in muscle tissues. May play a role in embryonic and central nervous system development. May be involved in the response to heart failure by elevating local creatine synthesis.

• Protein Families :
• Amidinotransferase family

• Research Area :
• Signal Transduction

• Tissue Specificity :
• Expressed in brain, heart, kidney, liver, lung, salivary gland and skeletal muscle tissue, with the highest expression in kidney. Biallelically expressed in placenta and fetal tissues.

• Weight :
• 44,943 Da

• Buffer :
• PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Form :
• Liquid

• Format :
• Liquid

• Purification :
• Antigen Affinity Purified

• Purity :
• Antigen Affinity Purified

• Storage :
• Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

• Storage Buffer :
• 
  
  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Datasheet :
• 

• ELISA Protocol :

• Western Blotting(WB) Protocol :

• Immunohistochemistry (IHC) Protocol :