HSD11B1 Antibody

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HSD11B1 Antibody

Alternative Names Corticosteroid 11-beta-dehydrogenase isozyme 1 (EC 1.1.1.146) (11-beta-hydroxysteroid dehydrogenase 1) (11-DH) (11-beta-HSD1) (Short chain...
Categories Primary Antibodies
Clonality polyclonal

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suppilerCUSABIO TECHONOLOGY LLC
merchant skuCSB-PA010763ESR2HU
item price299.00000
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suppilerCOHESION BIOSCIENCES
merchant skuCSB-PA010763ESR2HU
item price168.78000
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Description

Description

Alternative Names :
Corticosteroid 11-beta-dehydrogenase isozyme 1 (EC 1.1.1.146) (11-beta-hydroxysteroid dehydrogenase 1) (11-DH) (11-beta-HSD1) (Short chain dehydrogenase/reductase family 26C member 1), HSD11B1, HSD11 HSD11L SDR26C1

Categories :
Primary Antibodies

Clonality :
polyclonal

Description :
Catalyzes reversibly the conversion of cortisol to the inactive metabolite cortisone. Catalyzes reversibly the conversion of 7-ketocholesterol to 7-beta-hydroxycholesterol. In intact cells, the reaction runs only in one direction, from 7-ketocholesterol to 7-beta-hydroxycholesterol.

Host :
Rabbit

Immunogen :
Recombinant Human Corticosteroid 11-beta-dehydrogenase isozyme 1 protein (25-292AA)

Involvement In Disease :
Cortisone reductase deficiency 2 (CORTRD2)

Isotype :
IgG

Raised In :
Rabbit

Reactivity :
Human, Mouse

Regulatory :
RUO

Relevance :
Catalyzes reversibly the conversion of cortisol to the inactive metabolite cortisone. Catalyzes reversibly the conversion of 7-ketocholesterol to 7-beta-hydroxycholesterol. In intact cells, the reaction runs only in one direction, from 7-ketocholesterol to 7-beta-hydroxycholesterol.

Species :
Homo Sapiens (Human)

Subcellular Location :
Endoplasmic reticulum membrane, Single-pass type II membrane protein

Target

Target

Uniprot :
P28845

Database Links :
HGNC:5208
OMIM:600713
KEGG:hsa:3290
STRING:9606.ENSP00000261465
UniGene:Hs.195040

Function :
Catalyzes reversibly the conversion of cortisol to the inactive metabolite cortisone. Catalyzes reversibly the conversion of 7-ketocholesterol to 7-beta-hydroxycholesterol. In intact cells, the reaction runs only in one direction, from 7-ketocholesterol to 7-beta-hydroxycholesterol (By similarity).

Protein Families :
Short-chain dehydrogenases/reductases (SDR) family

Research Area :
Signal Transduction

Tissue Specificity :
Widely expressed. Highest expression in liver.

Property

Property

Buffer :
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form :
Liquid

Format :
Liquid

Purification :
Antigen Affinity Purified

Purity :
Antigen Affinity Purified

Storage :
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Storage Buffer :
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Applications

Applications

Application

Description

Dilution

Dilution: ELISA, WB, IHC

Dilution: ELISA ; WB ; IHC, WB ; ELISA ; IHC

Dilution:

WB	1:500-2000
IHC	1:20-1:200

Dilution: ELISA, WB, IHC; Recommended dilution: WB:1:500-1:2000, IHC:1:20-1:200

Protocols

Protocols

Datasheet :

ELISA Protocol :

Western Blotting(WB) Protocol :

Immunohistochemistry (IHC) Protocol :

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