• Alternative Names :
• Caspase-14 (CASP-14) (EC 3.4.22.-) [Cleaved into: Caspase-14 subunit p17, mature form; Caspase-14 subunit p10, mature form; Caspase-14 subunit p20, intermediate form; Caspase-14 subunit p8, intermediate form], CASP14

• Categories :
• Primary Antibodies

• Clonality :
• polyclonal

• Description :
• Believed to be a non-apoptotic caspase which is involved in epidermal differentiation. Seems to play a role in keratinocyte differentiation and cornification. Probably regulates maturation of the epidermis by proteolytically processing filaggrin.

• Host :
• Rabbit

• Immunogen :
• Recombinant Human Caspase-14 protein (1-242AA)

• Involvement In Disease :
• Ichthyosis, congenital, autosomal recessive 12 (ARCI12)

• Isotype :
• IgG

• Raised In :
• Rabbit

• Reactivity :
• Human

• Regulatory :
• RUO

• Relevance :
• Believed to be a non-apoptotic caspase which is involved in epidermal differentiation. Seems to play a role in keratinocyte differentiation and cornification. Probably regulates maturation of the epidermis by proteolytically processing filaggrin.

• Species :
• Homo Sapiens (Human)

• Subcellular Location :
• Cytoplasm, Nucleus

• Antigen :
• CASP14

• Uniprot :
• P31944

• Database Links :
• 
  

  HGNC:1502

  OMIM:605848

  KEGG:hsa:23581

  STRING:9606.ENSP00000221740

  UniGene:Hs.466057

• Function :
• Non-apoptotic caspase involved in epidermal differentiation. Is the predominant caspase in epidermal stratum corneum

• Protein Families :
• Peptidase C14A family

• Research Area :
• Cell Biology

• Tissue Specificity :
• Expressed in keratinocytes of adult skin suprabasal layers (from spinous layers to the stratum granulosum and stratum corneum) (at protein level). Expressed in keratinocytes of hair shaft and sebaceous glands (at protein level). In psoriatic skin only exp

• Buffer :
• PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Form :
• Liquid

• Format :
• Liquid

• Purification :
• Antigen Affinity Purified

• Purity :
• Antigen Affinity Purified

• Storage :
• Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

• Storage Buffer :
• 
  
  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Datasheet :
• 

• ELISA Protocol :

• Immunohistochemistry (IHC) Protocol :