• Alternative Names :
• Heat shock protein 105 kDa (Antigen NY-CO-25) (Heat shock 110 kDa protein), HSPH1, HSP105 HSP110 KIAA0201

• Categories :
• Primary Antibodies

• Clonality :
• polyclonal

• Description :
• Prevents the aggregation of denatured proteins in cells under severe stress, on which the ATP levels decrease markedly. Inhibits HSPA8/HSC70 ATPase and chaperone activities

• Host :
• Rabbit

• Immunogen :
• Recombinant Human Heat shock protein 105 kDa protein (659-858AA)

• Isotype :
• IgG

• Raised In :
• Rabbit

• Reactivity :
• Human, Mouse

• Regulatory :
• RUO

• Relevance :
• Prevents the aggregation of denatured proteins in cells under severe stress, on which the ATP levels decrease markedly. Inhibits HSPA8/HSC70 ATPase and chaperone activities

• Species :
• Homo Sapiens (Human)

• Subcellular Location :
• Cytoplasm

• Antigen :
• HSPH1

• Uniprot :
• Q92598

• Database Links :
• 
  

  HGNC:16969

  OMIM:610703

  KEGG:hsa:10808

  STRING:9606.ENSP00000318687

  UniGene:Hs.743267

• Function :
• Acts as a nucleotide-exchange factor (NEF) for chaperone proteins HSPA1A and HSPA1B, promoting the release of ADP from HSPA1A/B thereby triggering client/substrate protein release

• Pathway :
• Protein processing in endoplasmic reticulum

• Protein Families :
• Heat shock protein 70 family

• Research Area :
• Signal Transduction

• Tissue Specificity :
• Highly expressed in testis. Present at lower levels in most brain regions, except cerebellum. Overexpressed in cancer cells.

• Buffer :
• PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Form :
• Liquid

• Format :
• Liquid

• Purification :
• Antigen Affinity Purified

• Purity :
• Antigen Affinity Purified

• Storage :
• Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

• Storage Buffer :
• 
  
  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Datasheet :
• 

• ELISA Protocol :

• Western Blotting(WB) Protocol :

• Immunohistochemistry (IHC) Protocol :