• Alternative Names :
• Cathepsin K (EC 3.4.22.38) (Cathepsin O) (Cathepsin O2) (Cathepsin X), CTSK, CTSO CTSO2

• Categories :
• Primary Antibodies

• Clonality :
• polyclonal

• Description :
• Closely involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation.

• Host :
• Rabbit

• Immunogen :
• Recombinant Human Cathepsin K protein (115-329AA)

• Involvement In Disease :
• Pycnodysostosis (PKND)

• Isotype :
• IgG

• Raised In :
• Rabbit

• Reactivity :
• Human, Rat

• Regulatory :
• RUO

• Relevance :
• Closely involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation.

• Species :
• Homo Sapiens (Human)

• Subcellular Location :
• Lysosome

• Antigen :
• CTSK

• Uniprot :
• P43235

• Database Links :
• 
  

  HGNC:2536

  OMIM:265800

  KEGG:hsa:1513

  STRING:9606.ENSP00000271651

  UniGene:Hs.632466

• Function :
• Closely involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation.

• Pathway :
• Apoptosis Osteoclast differentiation Toll-like receptor signaling pathway

• Protein Families :
• Peptidase C1 family

• Research Area :
• Cardiovascular

• Tissue Specificity :
• Predominantly expressed in osteoclasts (bones).

• Buffer :
• PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Form :
• Liquid

• Format :
• Liquid

• Purification :
• Antigen Affinity Purified

• Purity :
• Antigen Affinity Purified

• Storage :
• Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

• Storage Buffer :
• 
  
  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Datasheet :
• 

• ELISA Protocol :

• Western Blotting(WB) Protocol :

• Immunohistochemistry (IHC) Protocol :