• Alternative Names :
• Kinesin-like protein KIF2C (Kinesin-like protein 6) (Mitotic centromere-associated kinesin) (MCAK), KIF2C, KNSL6

• Categories :
• Primary Antibodies

• Clonality :
• polyclonal

• Description :
• In complex with KIF18B, constitutes the major microtubule plus-end depolymerizing activity in mitotic cells. Regulates the turnover of microtubules at the kinetochore and functions in chromosome segregation during mitosis.

• Host :
• Rabbit

• Immunogen :
• Recombinant Human Kinesin-like protein KIF2C protein (1-190AA)

• Isotype :
• IgG

• Raised In :
• Rabbit

• Reactivity :
• Human

• Regulatory :
• RUO

• Relevance :
• In complex with KIF18B, constitutes the major microtubule plus-end depolymerizing activity in mitotic cells. Regulates the turnover of microtubules at the kinetochore and functions in chromosome segregation during mitosis.

• Species :
• Homo Sapiens (Human)

• Subcellular Location :
• Cytoplasm, cytoskeleton, Nucleus, Chromosome, centromere, Chromosome, centromere, kinetochore

• Antigen :
• KIF2C

• Uniprot :
• Q99661

• Database Links :
• 
  

  HGNC:6393

  OMIM:604538

  KEGG:hsa:11004

  STRING:9606.ENSP00000361298

  UniGene:Hs.720061

• Function :
• In complex with KIF18B, constitutes the major microtubule plus-end depolymerizing activity in mitotic cells

• Protein Families :
• TRAFAC class myosin-kinesin ATPase superfamily, Kinesin family, MCAK/KIF2 subfamily

• Research Area :
• Signal Transduction

• Tissue Specificity :
• Expressed at high levels in thymus and testis, at low levels in small intestine, the mucosal lining of colon, and placenta, and at very low levels in spleen and ovary; expression is not detected in prostate, peripheral blood Leukocytes, heart, brain, lung

• Buffer :
• PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Form :
• Liquid

• Format :
• Liquid

• Purification :
• Antigen Affinity Purified

• Purity :
• Antigen Affinity Purified

• Storage :
• Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

• Storage Buffer :
• 
  
  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Datasheet :
• 

• ELISA Protocol :

• Immunohistochemistry (IHC) Protocol :