• Alternative Names :
• Fibroblast growth factor 1 (FGF-1) (Acidic fibroblast growth factor) (aFGF) (Endothelial cell growth factor) (ECGF) (Heparin-binding growth factor 1) (HBGF-1), FGF1, FGFA

• Categories :
• Primary Antibodies

• Clonality :
• polyclonal

• Description :
• Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro.

• Host :
• Rabbit

• Immunogen :
• Recombinant Human Fibroblast growth factor 1 protein (16-155AA)

• Isotype :
• IgG

• Raised In :
• Rabbit

• Reactivity :
• Human

• Regulatory :
• RUO

• Relevance :
• Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro.

• Species :
• Homo Sapiens (Human)

• Subcellular Location :
• Secreted, Cytoplasm, Cytoplasm, cell cortex, Cytoplasm, cytosol, Nucleus

• Uniprot :
• P05230

• Gene Id :
• 2246

• Database Links :
• 
  

  HGNC:3665

  OMIM:131220

  KEGG:hsa:2246

  STRING:9606.ENSP00000338548

  UniGene:Hs.483635

• Function :
• Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrin ITGAV

• Pathway :
• Hippo signaling pathway MAPK signaling pathway PI3K-Akt signaling pathway Regulation of actin cytoskeleton Ras signaling pathway Rap1 signaling pathway

• Protein Families :
• Heparin-binding growth factors family

• Research Area :
• Cardiovascular

• Tissue Specificity :
• Predominantly expressed in kidney and brain. Detected at much lower levels in heart and skeletal muscle.

• Weight :
• 17,460 Da

• Buffer :
• PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Form :
• Liquid

• Format :
• Liquid

• Purification :
• Antigen Affinity Purified

• Purity :
• Antigen Affinity Purified

• Storage :
• Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

• Storage Buffer :
• 
  
  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Datasheet :
• 

• ELISA Protocol :

• Immunohistochemistry (IHC) Protocol :

• Immunofluorescence (IF) Protocol :