• Alternative Names :
• B-cell lymphoma/leukemia 11A (BCL-11A) (B-cell CLL/lymphoma 11A) (COUP-TF-interacting protein 1) (Ecotropic viral integration site 9 protein homolog) (EVI-9) (Zinc finger protein 856), BCL11A, CTIP1 EVI9 KIAA1809 ZNF856

• Categories :
• Primary Antibodies

• Clonality :
• polyclonal

• Description :
• Functions as a myeloid and B-cell proto-oncogene. May play important roles in leukemogenesis and hematopoiesis. An essential factor in lymphopoiesis, is required for B-cell formation in fetal liver. May function as a modulator of the transcriptional repression activity of ARP1.

• Host :
• Rabbit

• Immunogen :
• Recombinant Human B-cell lymphoma/leukemia 11A protein (1-230AA)

• Involvement In Disease :
• Intellectual developmental disorder with persistence of fetal hemoglobin (IDPFH)

• Isotype :
• IgG

• Raised In :
• Rabbit

• Reactivity :
• Human

• Regulatory :
• RUO

• Relevance :
• Functions as a myeloid and B-cell proto-oncogene. May play important roles in leukemogenesis and hematopoiesis. An essential factor in lymphopoiesis, is required for B-cell formation in fetal liver. May function as a modulator of the transcriptional repression activity of ARP1.

• Species :
• Homo Sapiens (Human)

• Subcellular Location :
• Cytoplasm, Nucleus, Note=Associates with the nuclear body, Colocalizes with SUMO1 and SENP2 in nuclear speckles (By similarity), SUBCELLULAR LOCATION: Isoform 2: Cytoplasm, Nucleus, Note=Predominantly localized in the nucleus in nuclear paraspeckles, SUBCELLULAR LOCATION: Isoform 3: Cytoplasm, Nucleus

• Antigen :
• BCL11A

• Uniprot :
• Q9H165

• Database Links :
• 
  

  HGNC:13221

  OMIM:142335

  KEGG:hsa:53335

  STRING:9606.ENSP00000338774

  UniGene:Hs.370549

• Function :
• Transcription factor associated with the BAF SWI/SNF chromatin remodeling complex (By similarity). Repressor of fetal hemoglobin (HbF) level

• Research Area :
• Epigenetics and Nuclear Signaling

• Tissue Specificity :
• Expressed at high levels in brain, spleen thymus, bone marrow and testis. Expressed in CD34-positive myeloid precursor cells, B-cells, monocytes and megakaryocytes. Expression is tightly regulated during B-cell development.

• Buffer :
• PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Form :
• Liquid

• Format :
• Liquid

• Purification :
• Antigen Affinity Purified

• Purity :
• Antigen Affinity Purified

• Storage :
• Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

• Storage Buffer :
• 
  
  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Datasheet :
• 

• ELISA Protocol :

• Immunohistochemistry (IHC) Protocol :