• Alternative Names :
• Forkhead box protein P2 (CAG repeat protein 44) (Trinucleotide repeat-containing gene 10 protein), FOXP2, CAGH44 TNRC10

• Categories :
• Primary Antibodies

• Clonality :
• polyclonal

• Description :
• Transcriptional repressor that may play a role in the specification and differentiation of lung epithelium. May also play a role in developing neural, gastrointestinal and cardiovascular tissues. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential. Plays a role in synapse formation by regulating SRPX2 levels. Involved in neural mechanisms mediating the development of speech and language.

• Host :
• Rabbit

• Immunogen :
• Recombinant Human Forkhead box protein P2 protein (416-715AA)

• Involvement In Disease :
• Speech-language disorder 1 (SPCH1)

• Isotype :
• IgG

• Raised In :
• Rabbit

• Reactivity :
• Human

• Regulatory :
• RUO

• Relevance :
• Transcriptional repressor that may play a role in the specification and differentiation of lung epithelium. May also play a role in developing neural, gastrointestinal and cardiovascular tissues. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential. Plays a role in synapse formation by regulating SRPX2 levels. Involved in neural mechanisms mediating the development of speech and language.

• Species :
• Homo Sapiens (Human)

• Subcellular Location :
• Nucleus

• Antigen :
• FOXP2

• Uniprot :
• O15409

• Database Links :
• 
  

  HGNC:13875

  OMIM:602081

  KEGG:hsa:93986

  STRING:9606.ENSP00000386200

  UniGene:Hs.282787

• Function :
• Transcriptional repressor that may play a role in the specification and differentiation of lung epithelium. May also play a role in developing neural, gastrointestinal and cardiovascular tissues. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential. Plays a role in synapse formation by regulating SRPX2 levels. Involved in neural mechanisms mediating the development of speech and language.

• Research Area :
• Epigenetics and Nuclear Signaling

• Tissue Specificity :
• Isoform 1 and isoform 6 are expressed in adult and fetal brain, caudate nucleus and lung.

• Buffer :
• PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Form :
• Liquid

• Format :
• Liquid

• Purification :
• Antigen Affinity Purified

• Purity :
• Antigen Affinity Purified

• Storage :
• Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

• Storage Buffer :
• 
  
  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Datasheet :
• 

• ELISA Protocol :

• Immunohistochemistry (IHC) Protocol :