HYAL3 Antibody

Alternative Names Hyaluronidase-3 (Hyal-3) (EC 3.2.1.35) (Hyaluronoglucosaminidase-3) (Lung carcinoma protein 3) (LuCa-3), HYAL3, LUCA3
Categories Primary Antibodies
Clonality polyclonal

Alternative Names :
Hyaluronidase-3 (Hyal-3) (EC 3.2.1.35) (Hyaluronoglucosaminidase-3) (Lung carcinoma protein 3) (LuCa-3), HYAL3, LUCA3

Subcellular Location :
Secreted, Cell membrane, Cytoplasmic vesicle, secretory vesicle, acrosome, Endoplasmic reticulum, Early endosome

Database Links :
HGNC:5322
OMIM:604038
KEGG:hsa:8372
STRING:9606.ENSP00000337425
UniGene:Hs.129910

Function :
Facilitates sperm penetration into the layer of cumulus cells surrounding the egg by digesting hyaluronic acid. Involved in induction of the acrosome reaction in the sperm. Involved in follicular atresia, the breakdown of immature ovarian follicles that are not selected to ovulate. Induces ovarian granulosa cell apoptosis, possibly via apoptotic signaling pathway involving CASP8 and CASP3 activation, and poly(ADP-ribose) polymerase (PARP) cleavage. Has no hyaluronidase activity in embryonic fibroblasts in vitro. Has no hyaluronidase activity in granulosa cells in vitro.

Tissue Specificity :
Expressed in sperm (PubMed:20586096). Highly expressed in epidermis of the skin, where it is expressed intracellularily in the deep horny layer (at protein level) (PubMed:21699545). Bone marrow, testis and kidney (PubMed:10493834).