• Alternative Names :
• Adenylosuccinate lyase (ADSL) (ASL) (EC 4.3.2.2) (Adenylosuccinase) (ASase), ADSL, AMPS

• Categories :
• Primary Antibodies

• Clonality :
• polyclonal

• Description :
• Catalyzes two non-sequential steps in de novo AMP synthesis: converts (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate (SAICAR) to fumarate plus 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide, and thereby also contributes to de novo IMP synthesis, and converts succinyladenosine monophosphate (SAMP) to AMP and fumarate.

• Host :
• Rabbit

• Immunogen :
• Recombinant Human Adenylosuccinate lyase protein (1-310AA)

• Involvement In Disease :
• Adenylosuccinase deficiency (ADSLD)

• Isotype :
• IgG

• Raised In :
• Rabbit

• Reactivity :
• Human, Mouse

• Regulatory :
• RUO

• Relevance :
• Catalyzes two non-sequential steps in de novo AMP synthesis: converts (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate (SAICAR) to fumarate plus 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide, and thereby also contributes to de novo IMP synthesis, and converts succinyladenosine monophosphate (SAMP) to AMP and fumarate.

• Species :
• Homo Sapiens (Human)

• Uniprot :
• P30566

• Gene Id :
• 158

• Database Links :
• 
  

  HGNC:291

  OMIM:103050

  KEGG:hsa:158

  STRING:9606.ENSP00000216194

  UniGene:Hs.75527

• Function :
• Catalyzes two non-sequential steps in de novo AMP synthesis

• Protein Families :
• Lyase 1 family, Adenylosuccinate lyase subfamily

• Research Area :
• Signal Transduction

• Tissue Specificity :
• Ubiquitously expressed. Both isoforms are produced by all tissues. Isoform 2 is 10-fold less abundant than isoform 1.

• Weight :
• 54kDa

• Buffer :
• PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Form :
• Liquid

• Format :
• Liquid

• Purification :
• Antigen Affinity Purified

• Purity :
• Antigen Affinity Purified

• Storage :
• Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

• Storage Buffer :
• 
  
  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Datasheet :
• 

• ELISA Protocol :

• Western Blotting(WB) Protocol :

• Immunohistochemistry (IHC) Protocol :