• Alternative Names :
• Cell division cycle 5-like protein (Cdc5-like protein) (Pombe cdc5-related protein), CDC5L, KIAA0432 PCDC5RP

• Categories :
• Primary Antibodies

• Clonality :
• polyclonal

• Description :
• DNA-binding protein involved in cell cycle control. May act as a transcription activator. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. The PRP19-CDC5L complex may also play a role in the response to DNA damage (DDR).

• Host :
• Rabbit

• Immunogen :
• Recombinant Human Cell division cycle 5-like protein (563-802AA)

• Involvement In Disease :
• A chromosomal aberration involving CDC5L is found in multicystic renal dysplasia. Translocation t(6;19)(p21;q13.1) with USF2.

• Isotype :
• IgG

• Raised In :
• Rabbit

• Reactivity :
• Human

• Regulatory :
• RUO

• Relevance :
• DNA-binding protein involved in cell cycle control. May act as a transcription activator. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. The PRP19-CDC5L complex may also play a role in the response to DNA damage (DDR).

• Species :
• Homo Sapiens (Human)

• Subcellular Location :
• Nucleus, Nucleus speckle, Cytoplasm

• Antigen :
• CDC5L

• Uniprot :
• Q99459

• Database Links :
• 
  

  HGNC:1743

  OMIM:602868

  KEGG:hsa:988

  STRING:9606.ENSP00000360532

  UniGene:Hs.485471

• Function :
• DNA-binding protein involved in cell cycle control. May act as a transcription activator. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. The PRP19-CDC5L complex may also play a role in the response to DNA damage (DDR).

• Protein Families :
• CEF1 family

• Research Area :
• Epigenetics and Nuclear Signaling

• Tissue Specificity :
• Ubiquitously expressed in both fetal and adult tissues.

• Buffer :
• PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Form :
• Liquid

• Format :
• Liquid

• Purification :
• Antigen Affinity Purified

• Purity :
• Antigen Affinity Purified

• Storage :
• Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

• Storage Buffer :
• 
  
  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Datasheet :
• 

• ELISA Protocol :

• Immunohistochemistry (IHC) Protocol :