• Alternative Names :
• Renin receptor (ATPase H(+)-transporting lysosomal accessory protein 2) (ATPase H(+)-transporting lysosomal-interacting protein 2) (ER-localized type I transmembrane adaptor) (Embryonic liver differentiation factor 10) (N14F) (Renin/prorenin receptor) (Vacuolar ATP synthase membrane sector-associated protein M8-9) (ATP6M8-9) (V-ATPase M8.9 subunit), ATP6AP2, ATP6IP2 CAPER ELDF10

• Categories :
• Primary Antibodies

• Clonality :
• polyclonal

• Description :
• Functions as a renin and prorenin cellular receptor. May mediate renin-dependent cellular responses by activating ERK1 and ERK2. By increasing the catalytic efficiency of renin in AGT/angiotensinogen conversion to angiotensin I, it may also play a role in the renin-angiotensin system (RAS).1 Publication

• Host :
• Rabbit

• Immunogen :
• Recombinant Human Renin receptor protein (251-350AA)

• Involvement In Disease :
• Mental retardation, X-linked, with epilepsy (MRXE); Parkinsonism with spasticity, X-linked (XPDS)

• Isotype :
• IgG

• Raised In :
• Rabbit

• Reactivity :
• Human, Mouse

• Regulatory :
• RUO

• Relevance :
• Functions as a renin and prorenin cellular receptor. May mediate renin-dependent cellular responses by activating ERK1 and ERK2. By increasing the catalytic efficiency of renin in AGT/angiotensinogen conversion to angiotensin I, it may also play a role in the renin-angiotensin system (RAS).1 Publication

• Species :
• Homo Sapiens (Human)

• Subcellular Location :
• Membrane, Single-pass type I membrane protein

• Antigen :
• ATP6AP2

• Uniprot :
• O75787

• Gene Id :
• 10159

• Database Links :
• 
  

  HGNC:18305

  OMIM:300423

  KEGG:hsa:10159

  STRING:9606.ENSP00000367697

  UniGene:Hs.495960

• Function :
• Functions as a renin and prorenin cellular receptor. May mediate renin-dependent cellular responses by activating ERK1 and ERK2. By increasing the catalytic efficiency of renin in AGT/angiotensinogen conversion to angiotensin I, it may also play a role in the renin-angiotensin system (RAS).

• Pathway :
• Renin-angiotensin system

• Research Area :
• Signal Transduction

• Tissue Specificity :
• Expressed in brain, heart, placenta, liver, kidney and pancreas. Barely detectable in lung and skeletal muscles. In the kidney cortex it is restricted to the mesangium of glomeruli. In the coronary and kidney artery it is expressed in the subendothelium,

• Weight :
• 35,612 Da

• Buffer :
• PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Form :
• Liquid

• Format :
• Liquid

• Purification :
• Antigen Affinity Purified

• Purity :
• Antigen Affinity Purified

• Storage :
• Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

• Storage Buffer :
• 
  
  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Datasheet :
• 

• ELISA Protocol :

• Western Blotting(WB) Protocol :

• Immunohistochemistry (IHC) Protocol :