• Alternative Names :
• Mitotic spindle assembly checkpoint protein MAD2A (HsMAD2) (Mitotic arrest deficient 2-like protein 1) (MAD2-like protein 1), MAD2L1, MAD2

• Categories :
• Primary Antibodies

• Clonality :
• polyclonal

• Description :
• Component of the spindle-assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. Required for the execution of the mitotic checkpoint which monitors the process of kinetochore-spindle attachment and inhibits the activity of the anaphase promoting complex by sequestering CDC20 until all chromosomes are aligned at the metaphase plate.

• Host :
• Rabbit

• Immunogen :
• Recombinant Human Mitotic spindle assembly checkpoint protein MAD2A protein (1-205AA)

• Isotype :
• IgG

• Raised In :
• Rabbit

• Reactivity :
• Human

• Regulatory :
• RUO

• Relevance :
• Component of the spindle-assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. Required for the execution of the mitotic checkpoint which monitors the process of kinetochore-spindle attachment and inhibits the activity of the anaphase promoting complex by sequestering CDC20 until all chromosomes are aligned at the metaphase plate.

• Species :
• Homo Sapiens (Human)

• Subcellular Location :
• Nucleus, Chromosome, centromere, kinetochore, Cytoplasm, Cytoplasm, cytoskeleton, spindle pole

• Antigen :
• MAD2L1

• Uniprot :
• Q13257

• Database Links :
• 
  

  HGNC:6763

  OMIM:601467

  KEGG:hsa:4085

  STRING:9606.ENSP00000296509

  UniGene:Hs.591697

• Function :
• Component of the spindle-assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. Required for the execution of the mitotic checkpoint which monitors the process of kinetochore-spindle attachment and inhibits the activity of the anaphase promoting complex by sequestering CDC20 until all chromosomes are aligned at the metaphase plate.

• Pathway :
• Cell cycle

• Protein Families :
• MAD2 family

• Research Area :
• Cell Biology

• Buffer :
• PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Form :
• Liquid

• Format :
• Liquid

• Purification :
• Antigen Affinity Purified

• Purity :
• Antigen Affinity Purified

• Storage :
• Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

• Storage Buffer :
• 
  
  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Datasheet :
• 

• ELISA Protocol :

• Immunohistochemistry (IHC) Protocol :