• Alternative Names :
• Histone acetyltransferase type B catalytic subunit (EC 2.3.1.48) (Histone acetyltransferase 1), HAT1, KAT1

• Categories :
• Primary Antibodies

• Clonality :
• polyclonal

• Description :
• Acetylates soluble but not nucleosomal histone H4 at 'Lys-5' (H4K5ac) and 'Lys-12' (H4K12ac) and, to a lesser extent, acetylates histone H2A at 'Lys-5' (H2AK5ac). Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. May be involved in nucleosome assembly during DNA replication and repair as part of the histone H3.1 and H3.3 complexes. May play a role in DNA repair in response to free radical damage.

• Host :
• Rabbit

• Immunogen :
• Recombinant Human Histone acetyltransferase type B catalytic subunit protein (245-419AA)

• Isotype :
• IgG

• Raised In :
• Rabbit

• Reactivity :
• Human

• Regulatory :
• RUO

• Relevance :
• Acetylates soluble but not nucleosomal histone H4 at 'Lys-5' (H4K5ac) and 'Lys-12' (H4K12ac) and, to a lesser extent, acetylates histone H2A at 'Lys-5' (H2AK5ac). Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. May be involved in nucleosome assembly during DNA replication and repair as part of the histone H3.1 and H3.3 complexes. May play a role in DNA repair in response to free radical damage.

• Species :
• Homo Sapiens (Human)

• Subcellular Location :
• Isoform A: Nucleus matrix, SUBCELLULAR LOCATION: Isoform B: Cytoplasm, Nucleus, Nucleus matrix, Nucleus, nucleoplasm

• Antigen :
• HAT1

• Uniprot :
• O14929

• Database Links :
• 
  

  HGNC:4821

  OMIM:603053

  KEGG:hsa:8520

  STRING:9606.ENSP00000264108

  UniGene:Hs.632532

• Function :
• Acetylates soluble but not nucleosomal histone H4 at 'Lys-5' (H4K5ac) and 'Lys-12' (H4K12ac) and, to a lesser extent, acetylates histone H2A at 'Lys-5' (H2AK5ac). Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. May be involved in nucleosome assembly during DNA replication and repair as part of the histone H3.1 and H3.3 complexes. May play a role in DNA repair in response to free radical damage.

• Protein Families :
• HAT1 family

• Research Area :
• Epigenetics and Nuclear Signaling

• Buffer :
• PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Form :
• Liquid

• Format :
• Liquid

• Purification :
• Antigen Affinity Purified

• Purity :
• Antigen Affinity Purified

• Storage :
• Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

• Storage Buffer :
• 
  
  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Datasheet :
• 

• ELISA Protocol :

• Western Blotting(WB) Protocol :

• Immunohistochemistry (IHC) Protocol :