• Alternative Names :
• Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial (P5C dehydrogenase) (EC 1.2.1.88) (Aldehyde dehydrogenase family 4 member A1) (L-glutamate gamma-semialdehyde dehydrogenase), ALDH4A1, ALDH4 P5CDH

• Categories :
• Primary Antibodies

• Clonality :
• polyclonal

• Description :
• Irreversible conversion of delta-1-pyrroline-5-carboxylate (P5C), derived either from proline or ornithine, to glutamate. This is a necessary step in the pathway interconnecting the urea and tricarboxylic acid cycles. The preferred substrate is glutamic gamma-semialdehyde, other substrates include succinic, glutaric and adipic semialdehydes.

• Host :
• Rabbit

• Immunogen :
• Recombinant Human Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial protein (354-563AA)

• Involvement In Disease :
• Hyperprolinemia 2 (HYRPRO2)

• Isotype :
• IgG

• Raised In :
• Rabbit

• Reactivity :
• Human

• Regulatory :
• RUO

• Relevance :
• Irreversible conversion of delta-1-pyrroline-5-carboxylate (P5C), derived either from proline or ornithine, to glutamate. This is a necessary step in the pathway interconnecting the urea and tricarboxylic acid cycles. The preferred substrate is glutamic gamma-semialdehyde, other substrates include succinic, glutaric and adipic semialdehydes.

• Species :
• Homo Sapiens (Human)

• Subcellular Location :
• Mitochondrion matrix

• Antigen :
• ALDH4A1

• Uniprot :
• P30038

• Gene Id :
• 8659

• Database Links :
• 
  

  HGNC:406

  OMIM:239510

  KEGG:hsa:8659

  STRING:9606.ENSP00000290597

  UniGene:Hs.77448

• Function :
• Irreversible conversion of delta-1-pyrroline-5-carboxylate (P5C), derived either from proline or ornithine, to glutamate. This is a necessary step in the pathway interconnecting the urea and tricarboxylic acid cycles. The preferred substrate is glutamic gamma-semialdehyde, other substrates include succinic, glutaric and adipic semialdehydes.

• Protein Families :
• Aldehyde dehydrogenase family

• Research Area :
• Tags & Cell Markers

• Tissue Specificity :
• Highest expression is found in liver followed by skeletal muscle, kidney, heart, brain, placenta, lung and pancreas.

• Weight :
• 61,719 Da

• Buffer :
• PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Form :
• Liquid

• Format :
• Liquid

• Purification :
• Antigen Affinity Purified

• Purity :
• Antigen Affinity Purified

• Storage :
• Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

• Storage Buffer :
• 
  
  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Datasheet :
• 

• ELISA Protocol :

• Western Blotting(WB) Protocol :

• Immunohistochemistry (IHC) Protocol :