• Alternative Names :
• Receptor tyrosine-protein kinase erbB-3 (EC 2.7.10.1) (Proto-oncogene-like protein c-ErbB-3) (Tyrosine kinase-type cell surface receptor HER3), ERBB3, HER3

• Categories :
• Primary Antibodies

• Clonality :
• polyclonal

• Description :
• Binds and is activated by neuregulins and NTAK.

• Host :
• Rabbit

• Immunogen :
• Recombinant Human Receptor tyrosine-protein kinase erbB-3 protein (20-285AA)

• Involvement In Disease :
• Lethal congenital contracture syndrome 2 (LCCS2)

• Isotype :
• IgG

• Raised In :
• Rabbit

• Reactivity :
• Human

• Regulatory :
• RUO

• Relevance :
• Binds and is activated by neuregulins and NTAK.

• Species :
• Homo Sapiens (Human)

• Subcellular Location :
• Isoform 1: Cell membrane, Single-pass type I membrane protein, SUBCELLULAR LOCATION: Isoform 2: Secreted

• Antigen :
• ERBB3

• Uniprot :
• P21860

• Database Links :
• 
  

  HGNC:3431

  OMIM:190151

  KEGG:hsa:2065

  STRING:9606.ENSP00000267101

  UniGene:Hs.118681

• Function :
• Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins. Binds to neuregulin-1 (NRG1) and is activated by it; ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase

• Pathway :
• Calcium signaling pathway ErbB signaling pathway MAPK signaling pathway PI3K-Akt signaling pathway

• Protein Families :
• Protein kinase superfamily, Tyr protein kinase family, EGF receptor subfamily

• Research Area :
• Tags & Cell Markers

• Tissue Specificity :
• Epithelial tissues and brain.

• Buffer :
• PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Form :
• Liquid

• Format :
• Liquid

• Purification :
• Antigen Affinity Purified

• Purity :
• Antigen Affinity Purified

• Storage :
• Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

• Storage Buffer :
• 
  
  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Datasheet :
• 

• ELISA Protocol :

• Immunohistochemistry (IHC) Protocol :