• Alternative Names :
• Glutamate receptor 1 (GluR-1) (AMPA-selective glutamate receptor 1) (GluR-A) (GluR-K1) (Glutamate receptor ionotropic, AMPA 1) (GluA1), GRIA1, GLUH1 GLUR1

• Categories :
• Primary Antibodies

• Clonality :
• polyclonal

• Description :
• Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.

• Host :
• Rabbit

• Immunogen :
• Recombinant Human Glutamate receptor 1 protein (19-300AA)

• Isotype :
• IgG

• Raised In :
• Rabbit

• Reactivity :
• Human

• Regulatory :
• RUO

• Relevance :
• Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.

• Species :
• Homo Sapiens (Human)

• Subcellular Location :
• Cell membrane, Multi-pass membrane protein, Endoplasmic reticulum membrane, Multi-pass membrane protein, Cell junction, synapse, postsynaptic cell membrane, Multi-pass membrane protein, Cell junction, synapse, postsynaptic cell membrane, postsynaptic density, Multi-pass membrane protein, Cell projection, dendrite, Cell projection, dendritic spine, Early endosome membrane, Multi-pass membrane protein, Recycling endosome membrane, Multi-pass membrane protein

• Antigen :
• GRIA1

• Uniprot :
• P42261

• Gene Id :
• 2890

• Database Links :
• 
  

  HGNC:4571

  OMIM:138248

  KEGG:hsa:2890

  STRING:9606.ENSP00000285900

  UniGene:Hs.519693

• Function :
• Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.

• Pathway :
• cAMP signaling pathway Glutamatergic synapse

• Protein Families :
• Glutamate-gated ion channel (TC 1.A.10.1) family, GRIA1 subfamily

• Research Area :
• Neuroscience

• Tissue Specificity :
• Widely expressed in brain.

• Weight :
• 102kDa

• Buffer :
• PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Form :
• Liquid

• Format :
• Liquid

• Purification :
• Antigen Affinity Purified

• Purity :
• Antigen Affinity Purified

• Storage :
• Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

• Storage Buffer :
• 
  
  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Datasheet :
• 

• ELISA Protocol :

• Immunohistochemistry (IHC) Protocol :