HIP1 Antibody

Alternative Names Huntingtin-interacting protein 1 (HIP-1) (Huntingtin-interacting protein I) (HIP-I), HIP1
Categories Primary Antibodies
Clonality polyclonal

Alternative Names :
Huntingtin-interacting protein 1 (HIP-1) (Huntingtin-interacting protein I) (HIP-I), HIP1

Description :
Plays a role in clathrin-mediated endocytosis and trafficking. Involved in regulating AMPA receptor trafficking in the central nervous system in an NMDA-dependent manner. Enhances androgen receptor (AR)-mediated transcription. May act as a proapoptotic protein that induces cell death by acting through the intrinsic apoptosis pathway. Binds 3-phosphoinositides (via ENTH domain). May act through the ENTH domain to promote cell survival by stabilizing receptor tyrosine kinases following ligand-induced endocytosis. May play a functional role in the cell filament networks. May be required for differentiation, proliferation, and/or survival of somatic and germline progenitors.

Immunogen :
Recombinant Human Huntingtin-interacting protein 1 protein (410-690AA), Recombinant Human Huntingtin-interacting protein 1 protein (410-690AA)

Involvement In Disease :
A chromosomal aberration involving HIP1 is found in a form of chronic myelomonocytic leukemia (CMML). Translocation t(5;7)(q33;q11.2) with PDGFRB (PubMed:9616134). The chimeric HIP1-PDGFRB transcript results from an in-frame fusion of the two genes (PubMed:9616134). The reciprocal PDGFRB-HIP1 transcript is not expressed (PubMed:9616134).

Relevance :
Plays a role in clathrin-mediated endocytosis and trafficking. Involved in regulating AMPA receptor trafficking in the central nervous system in an NMDA-dependent manner. Enhances androgen receptor (AR)-mediated transcription. May act as a proapoptotic protein that induces cell death by acting through the intrinsic apoptosis pathway. Binds 3-phosphoinositides (via ENTH domain). May act through the ENTH domain to promote cell survival by stabilizing receptor tyrosine kinases following ligand-induced endocytosis. May play a functional role in the cell filament networks. May be required for differentiation, proliferation, and/or survival of somatic and germline progenitors., Plays a role in clathrin-mediated endocytosis and trafficking. Involved in regulating AMPA receptor trafficking in the central nervous system in an NMDA-dependent manner. Enhances androgen receptor (AR)-mediated transcription. May act as a proapoptotic protein that induces cell death by acting through the intrinsic apoptosis pathway. Binds 3-phosphoinositides (via ENTH domain). May act through the ENTH domain to promote cell survival by stabilizing receptor tyrosine kinases following ligand-induced endocytosis. May play a functional role in the cell filament networks. May be required for differentiation, proliferation, and/or survival of somatic and germline progenitors.

Subcellular Location :
Cytoplasm, Nucleus, Endomembrane system, Cytoplasmic vesicle, clathrin-coated vesicle membrane, Cytoplasm, Nucleus, Endomembrane system, Cytoplasmic vesicle, clathrin-coated vesicle membrane

Function :
Plays a role in clathrin-mediated endocytosis and trafficking, Plays a role in clathrin-mediated endocytosis and trafficking

Tissue Specificity :
Ubiquitously expressed with the highest level in brain. Expression is up-regulated in prostate and colon cancer., Ubiquitously expressed with the highest level in brain. Expression is up-regulated in prostate and colon cancer.