• Alternative Names :
• YTH domain-containing family protein 2 (CLL-associated antigen KW-14) (High-glucose-regulated protein 8) (Renal carcinoma antigen NY-REN-2), YTHDF2, HGRG8

• Categories :
• Primary Antibodies

• Clonality :
• polyclonal

• Description :
• Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, and regulates mRNA stability (PubMed:24284625, PubMed:26046440). M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in the efficiency of mRNA splicing, processing and stability (PubMed:22575960, PubMed:24284625, PubMed:25412658, PubMed:25412661). Acts as a regulator of mRNA stability: binding to m6A-containing mRNAs results in the localization to mRNA decay sites, such as processing bodies (P-bodies), leading to mRNA degradation (PubMed:24284625, PubMed:26046440).

• Host :
• Rabbit

• Immunogen :
• Recombinant Human YTH domain-containing family protein 2 protein (201-500AA)

• Isotype :
• IgG

• Raised In :
• Rabbit

• Reactivity :
• Human

• Regulatory :
• RUO

• Relevance :
• Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, and regulates mRNA stability (PubMed:24284625, PubMed:26046440). M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in the efficiency of mRNA splicing, processing and stability (PubMed:22575960, PubMed:24284625, PubMed:25412658, PubMed:25412661). Acts as a regulator of mRNA stability: binding to m6A-containing mRNAs results in the localization to mRNA decay sites, such as processing bodies (P-bodies), leading to mRNA degradation (PubMed:24284625, PubMed:26046440).

• Species :
• Homo Sapiens (Human)

• Subcellular Location :
• Cytoplasm, cytosol, Nucleus, Cytoplasm, P-body, Cytoplasm, cytosol, Nucleus, Cytoplasm, P-body

• Uniprot :
• Q9Y5A9

• Database Links :
• 
  

  HGNC:31675

  OMIM:610640

  KEGG:hsa:51441

  STRING:9606.ENSP00000362918

  UniGene:Hs.532286

• Function :
• Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, and regulates mRNA stability, Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, and regulates mRNA stability

• Protein Families :
• YTHDF2 family, YTHDF2 family

• Research Area :
• Cell Biology, Cell Biology

• Buffer :
• Preservative: 0.03% Proclin 300
  Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

• Form :
• Liquid, Liquid

• Format :
• Liquid, Liquid

• Purification :
• >95%, Protein G purified

• Purity :
• >95%,Protein G purified

• Storage :
• Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

• Storage Buffer :
• 
  
  Preservative: 0.03% Proclin 300
  Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

• Datasheet :
• 

• ELISA Protocol :