• Alternative Names :
• Peroxiredoxin-1 (EC 1.11.1.15) (Natural killer cell-enhancing factor A) (NKEF-A) (Proliferation-associated gene protein) (PAG) (Thioredoxin peroxidase 2) (Thioredoxin-dependent peroxide reductase 2), PRDX1, PAGA PAGB TDPX2

• Categories :
• Primary Antibodies

• Clonality :
• polyclonal

• Description :
• Involved in redox regulation of the cell. Reduces peroxides with reducing equivalents provided through the thioredoxin system but not from glutaredoxin. May play an important role in eliminating peroxides generated during metabolism. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H2O2. Reduces an intramolecular disulfide bond in GDPD5 that gates the ability to GDPD5 to drive postmitotic motor neuron differentiation

• Host :
• Rabbit

• Immunogen :
• Recombinant Human Peroxiredoxin-1 protein (1-199AA)

• Isotype :
• IgG

• Raised In :
• Rabbit

• Reactivity :
• Human

• Regulatory :
• RUO

• Relevance :
• Involved in redox regulation of the cell. Reduces peroxides with reducing equivalents provided through the thioredoxin system but not from glutaredoxin. May play an important role in eliminating peroxides generated during metabolism. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H2O2. Reduces an intramolecular disulfide bond in GDPD5 that gates the ability to GDPD5 to drive postmitotic motor neuron differentiation

• Species :
• Homo Sapiens (Human)

• Subcellular Location :
• Cytoplasm, Melanosome, Cytoplasm, Melanosome

• Uniprot :
• Q06830

• Database Links :
• 
  

  HGNC:9352

  OMIM:176763

  KEGG:hsa:5052

  STRING:9606.ENSP00000262746

  UniGene:Hs.180909

  ,
  

  HGNC:9352

  OMIM:176763

  KEGG:hsa:5052

  STRING:9606.ENSP00000262746

  UniGene:Hs.180909

• Function :
• Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2)

• Pathway :
• Cell ageing and metabolism

• Protein Families :
• Peroxiredoxin family, AhpC/Prx1 subfamily, Peroxiredoxin family, AhpC/Prx1 subfamily

• Research Area :
• Cell Biology

• Buffer :
• PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Form :
• Liquid

• Format :
• Liquid, Liquid

• Purification :
• Antigen Affinity Purified

• Purity :
• Antigen Affinity Purified

• Storage :
• Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

• Storage Buffer :
• 
  
  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Datasheet :
• 

• ELISA Protocol :
• 

• Western Blotting(WB) Protocol :

• Datasheet :