• Alternative Names :
• Ataxin-1 (Spinocerebellar ataxia type 1 protein), ATXN1, ATX1 SCA1

• Categories :
• Primary Antibodies

• Clonality :
• polyclonal

• Description :
• Chromatin-binding factor that repress Notch signaling in the absence of Notch intracellular domain by acting as a CBF1 corepressor. Binds to the HEY promoter and might assist, along with NCOR2, RBPJ-mediated repression. Binds RNA in vitro. May be involved in RNA metabolism. The expansion of the polyglutamine tract may alter this function.

• Host :
• Rabbit

• Immunogen :
• Recombinant Human Ataxin-1 protein (586-815AA)

• Involvement In Disease :
• Spinocerebellar ataxia 1 (SCA1)

• Isotype :
• IgG

• Raised In :
• Rabbit

• Reactivity :
• Human

• Regulatory :
• RUO

• Relevance :
• Chromatin-binding factor that repress Notch signaling in the absence of Notch intracellular domain by acting as a CBF1 corepressor. Binds to the HEY promoter and might assist, along with NCOR2, RBPJ-mediated repression. Binds RNA in vitro. May be involved in RNA metabolism. The expansion of the polyglutamine tract may alter this function.

• Species :
• Homo Sapiens (Human)

• Subcellular Location :
• Cytoplasm, Nucleus

• Antigen :
• ATXN1

• Uniprot :
• P54253

• Gene Id :
• 6310

• Database Links :
• 
  

  HGNC:10548

  OMIM:164400

  KEGG:hsa:6310

  STRING:9606.ENSP00000244769

  UniGene:Hs.434961

• Function :
• Chromatin-binding factor that repress Notch signaling in the absence of Notch intracellular domain by acting as a CBF1 corepressor. Binds to the HEY promoter and might assist, along with NCOR2, RBPJ-mediated repression. Binds RNA in vitro. May be involved in RNA metabolism

• Protein Families :
• ATXN1 family

• Research Area :
• Epigenetics and Nuclear Signaling

• Tissue Specificity :
• Widely expressed throughout the body.

• Weight :
• 86,923 Da

• Buffer :
• PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Form :
• Liquid

• Format :
• Liquid

• Purification :
• Antigen Affinity Purified

• Purity :
• Antigen Affinity Purified

• Storage :
• Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

• Storage Buffer :
• 
  
  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Datasheet :
• 

• ELISA Protocol :

• Immunohistochemistry (IHC) Protocol :