• Alternative Names :
• Granulins (Proepithelin) (PEPI) [Cleaved into: Acrogranin (Glycoprotein of 88 Kda) (GP88) (Glycoprotein 88) (Progranulin); Paragranulin; Granulin-1 (Granulin G); Granulin-2 (Granulin F); Granulin-3 (Granulin B); Granulin-4 (Granulin A); Granulin-5 (Granulin C); Granulin-6 (Granulin D); Granulin-7 (Granulin E)], GRN

• Categories :
• Primary Antibodies

• Clonality :
• polyclonal

• Description :
• Granulins have possible cytokine-like activity. They may play a role in inflammation, wound repair, and tissue remodeling. Granulin-4 promotes proliferation of the epithelial cell line A431 in culture while granulin-3 acts as an antagonist to granulin-4, inhibiting the growth.

• Host :
• Rabbit

• Immunogen :
• Recombinant Human Granulins protein (20-310AA)

• Involvement In Disease :
• Ubiquitin-positive frontotemporal dementia (UP-FTD); Ceroid lipofuscinosis, neuronal, 11 (CLN11)

• Isotype :
• IgG

• Raised In :
• Rabbit

• Reactivity :
• Human

• Regulatory :
• RUO

• Relevance :
• Granulins have possible cytokine-like activity. They may play a role in inflammation, wound repair, and tissue remodeling. Granulin-4 promotes proliferation of the epithelial cell line A431 in culture while granulin-3 acts as an antagonist to granulin-4, inhibiting the growth.

• Species :
• Homo Sapiens (Human)

• Subcellular Location :
• Secreted

• Antigen :
• GRN

• Uniprot :
• P28799

• Database Links :
• 
  

  HGNC:4601

  OMIM:138945

  KEGG:hsa:2896

  STRING:9606.ENSP00000053867

  UniGene:Hs.514220

• Function :
• Granulins have possible cytokine-like activity. They may play a role in inflammation, wound repair, and tissue remodeling.; FUNCTION

• Protein Families :
• Granulin family

• Research Area :
• Neuroscience

• Tissue Specificity :
• In myelogenous leukemic cell lines of promonocytic, promyelocytic, and proerythroid lineage, in fibroblasts, and very strongly in epithelial cell lines. Present in inflammatory cells and bone marrow. Highest levels in kidney.

• Buffer :
• PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Form :
• Liquid

• Format :
• Liquid

• Purification :
• Antigen Affinity Purified

• Purity :
• Antigen Affinity Purified

• Storage :
• Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

• Storage Buffer :
• 
  
  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Datasheet :
• 

• ELISA Protocol :

• Immunohistochemistry (IHC) Protocol :