• Alternative Names :
• Pyrroline-5-carboxylate reductase 2 (P5C reductase 2) (P5CR 2) (EC 1.5.1.2), PYCR2

• Categories :
• Primary Antibodies

• Clonality :
• polyclonal

• Description :
• Housekeeping enzyme that catalyzes the last step in proline biosynthesis. In some cell types, such as erythrocytes, its primary function may be the generation of NADP(+). Can utilize both NAD and NADP. Has higher affinity for NADP, but higher catalytic efficiency with NADH (PubMed:2722838, PubMed:6894153). Involved in cellular response to oxidative stress (PubMed:25865492).

• Host :
• Rabbit

• Immunogen :
• Recombinant Human Pyrroline-5-carboxylate reductase 2 protein (2-320AA)

• Involvement In Disease :
• Leukodystrophy, hypomyelinating, 10 (HLD10)

• Isotype :
• IgG

• Raised In :
• Rabbit

• Reactivity :
• Human

• Regulatory :
• RUO

• Relevance :
• Housekeeping enzyme that catalyzes the last step in proline biosynthesis. In some cell types, such as erythrocytes, its primary function may be the generation of NADP(+). Can utilize both NAD and NADP. Has higher affinity for NADP, but higher catalytic efficiency with NADH (PubMed:2722838, PubMed:6894153). Involved in cellular response to oxidative stress (PubMed:25865492).

• Species :
• Homo Sapiens (Human)

• Subcellular Location :
• Cytoplasm, Mitochondrion

• Uniprot :
• Q96C36

• Database Links :
• 
  

  HGNC:30262

  OMIM:616406

  KEGG:hsa:29920

  STRING:9606.ENSP00000342502

  UniGene:Hs.654718

• Function :
• Housekeeping enzyme that catalyzes the last step in proline biosynthesis. In some cell types, such as erythrocytes, its primary function may be the generation of NADP(+). Can utilize both NAD and NADP. Has higher affinity for NADP, but higher catalytic efficiency with NADH

• Protein Families :
• Pyrroline-5-carboxylate reductase family

• Research Area :
• Signal Transduction

• Tissue Specificity :
• Detected in erythrocytes (at protein level) (PubMed:2722838, PubMed:6894153). Expressed in fetal brain (PubMed:25865492).

• Buffer :
• Preservative: 0.03% Proclin 300
  Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

• Form :
• Liquid

• Format :
• Liquid

• Purification :
• Antigen Affinity Purified

• Purity :
• >95%,Protein G purified

• Storage :
• Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

• Storage Buffer :
• 
  
  Preservative: 0.03% Proclin 300
  Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

• Datasheet :
• 

• ELISA Protocol :