Kupffer Cells, also known as Browicz-Kupffer cells and stellate macrophages, are specialized macrophages located in the liver lining the walls of the sinusoids. Upon activation Kupffer cells release various products like cytokines, prostanoides, nitric oxide and reactive oxygen species. These factors determine the phenotypes of the Kupffer Cells and their neighbouring cells, such as hepatocytes, stellate cells, endothelial cells and other immune cells that travel through the liver. Therefore, kupffer cells are perfect for studying liver's response to infection, toxins, ischemia, resection and other stresses.
Density
100,000 cells/cm2
Growth Properties
Adherent
Quantity
1x106 cells / 1.0 ml
Morphology
Polygonal
Organism
Homo sapiens
Species
Human
Propagation
Use of PriCoatTM T25 Flasks (G299) or Applied Cell Extracellular Matrix (G422) is required for cell adhesion to the culture vessels. PriGrow X Series Medium (TM5549) + 1% Penicillin/Streptomycin Solution (G255), 37.0°C, 5% CO?.
Source Organ
Liver
Shipping
Dry Ice
Storage
-180°C
Reviews of Normal Human Primary Hepatic Kupffer Cells