Human CD8+ Cytotoxic T cells are a sub-group of T lymphocytes that are capable of inducing the death of infected somatic {with viruses or other pathogens) or tumor cells. Most CD8+ Cytotoxic T cells express T-cell receptors (TCRs) that can recognize a specific antigenic peptide bound to Class I MHC molecules (present on all nucleated cells) and a glycoprotein called CD8. The MHC molecule keeps the Cytotoxic T cell and the target cell bound closely together during antigen-specific activation. CD8+ T cells are recognized as Cytotoxic T cells once they become activated and are generally classified as having a pre-defined cytotoxic role within the immune system.
Cell Type
Primary Cells
Disclaimer
1. All test parameters provided in the CoA are conducted using abm's standardized culture system and procedures. The stated values may vary under the end-user's culture conditions. Please verify that the product is suitable for your studies by referencing published papers. All sales are final.2. If frozen cells were received and not recovered in your lab under the exact, specified conditions (using recommended culture vessel, media, additional supplements, and atmospheric conditions), a replacement is possible at a cost (plus shipping).3. All of abm's cell biology products are for research use ONLY and NOT for therapeutic/diagnostic applications. abm is not liable for any repercussions arising from the use of its cell biology product(s) in therapeutic/diagnostic application(s). Please contact a technical service representative for more information.4. abm makes no warranties or representations as to the accuracy of the information on this site. Citations from literature and provided for informational purposes only. abm does not warrant that such information has been shown to be accurate.
Disease
Normal
Gender
Donor Info Not Disclosed
Growth Properties
Suspension
Quantity
5x105 cells / 1.0 ml
Tissue
Blood
Morphology
Spherical
Species
Human (H. sapiens)
Propagation
The base medium for this cell line is Prigrow X series medium available at abm, Cat. No. TM4121. Human CD8+ Cytotoxic Killer T Cells do not proliferate in vitro. Carbon dioxide (CO2): 5%, Temperature: 37.0°C.
Applications
For Research Use Only, The most common applications of CD8+ Cytotoxic T cells are ELISPOT and Cytotoxicity assays