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Home / Primary Antibodies / Monoclonal Antibodies

VPS35 Antibody, Clone 10A8 (SMC-605)

SKU : BHA11933331

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StressMarq Biosciences Inc.

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Mfr.No.	SMC-605, SMC-605D, SMC-605D-A390, SMC-605D-A488, SMC-605D-A594, SMC-605D-APC, SMC-605D-BI, SMC-605D-FITC, SMC-605D-HRP, SMC-605D-PCP, SMC-605D-RPE, SMC-605S
Immunogen Species	Human
Alternative Names	Vacuolar protein sorting-associated protein 35, MEM3, PARK17, VPS35 retromer complex component, maternal-embryonic 3, vesicle protein sortin 35, TCCCTA00141, FLJ10752
Categories	Antibodies
Cellular Localization	Vesicles, Endosome, Lysosome, Cytoplasm, Membrane
Certificate Of Analysis	A 1:1000 dilution of SMC-605 was sufficient for detection of VPS35 in 10 ug of SH-SY5Y by ECL immunoblot analysis using Goat Anti-Mouse IgG:HRP as the secondary antibody.
Clonality	Monoclonal
Description	Mouse Anti-Human VPS35 Monoclonal IgG2a
Field Of Use	Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
Host	Mouse
Gross Weight (kg)	1.4
Immunogen Region	Full length recombinant human VSP35
Isotype	IgG2a
Launch Date	2019/07/17
Net Weight (g)	0.1
Reactivity	Human, Mouse, Rat
Species Reactivity Medium	Mouse, Rat, Human
Tissue Specificity	Ubiquitous. Highly expressed in brain, colon, heart, kidney, ovary, placenta, skeletal muscle, small intestine, testis, thymus.

Antigen	VPS35
Swissprot	Q96QK1
Accession Number	NP_060676.2
Gene Id	55737
Clone No	10A8
Research Area	Neuroscience \|Neurodegeneration, Membrane Trafficking Proteins, Cell Signaling, Parkinson's Disease, Golgi Proteins, Alzheimer's Disease, Protein Trafficking

Buffer	PBS pH 7.4, 50% glycerol, 0.09% Sodium Azide
Concentration	1 mg/ml
Purification	Protein G Purified
Scientific Background	Vacuolar Protein Sorter-35 (VPS35) is a component of the retromer complex, which is essential for endosome-to-Golgi retrieval of membrane proteins. VPS35 mutations such as D620N have been linked to Parkinson s Disease (PD) (1,2) and affect retromer function, protein homeostasis, and mitochondria (3).
Shipping Temperature	Blue Ice or 4°C
Specificity	Detects ~92 kDa.
Storage	-20ÂºC
Storage Buffer	PBS pH 7.4, 50% glycerol, 0.09% Sodium azide *Storage buffer may change when conjugated
Storage Temperature	-20°C

Applications	WB, ICC/IF, IP, IHC
Dilution	WB (1:1000); ICC/IF (1:200); IP (1:200); IHC (1:100); optimal dilutions for assays should be determined by the user.; optimal dilutions for assays should be determined by the user.

Product Manual	SDS

Reference	1. Vilarino-Guell, C. et al. (2011) Am J Hum Genet 89:162167 2. Zimprich, A. et al. (2011) Am J Hum Genet 89:168175 3. Rahman, A.A., Morrison, B.E. (2019) Neurosci 401:1-10.

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Combination SKU	Supplier No.	Conjugate	Size	Your price	Quantity
BHA11933331-1	SMC-605D	Unconjugated	100 ug	$395		Add to Cart
BHA11933331-2	SMC-605D-A390	ATTO 390	100 ug	$450		Add to Cart
BHA11933331-3	SMC-605D-A488	ATTO 488	100 ug	$449		Add to Cart
BHA11933331-4	SMC-605D-A594	ATTO 594	100 ug	$449		Add to Cart
BHA11933331-5	SMC-605D-APC	APC	100 ug	$448		Add to Cart
BHA11933331-6	SMC-605D-BI	Biotin	100 ug	$445		Add to Cart
BHA11933331-7	SMC-605D-FITC	FITC	100 ug	$440		Add to Cart
BHA11933331-8	SMC-605D-HRP	HRP	100 ug	$436		Add to Cart
BHA11933331-9	SMC-605D-PCP	PerCP	100 ug	$448		Add to Cart
BHA11933331-10	SMC-605D-RPE	RPE	100 ug	$446		Add to Cart
BHA11933331-11	SMC-605S	Unconjugated	12 ug	$45		Add to Cart

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