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Home / Primary Antibodies / Polyclonal Antibodies

Tuberin-Specific antibody

SKU : BHA10809093

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Mfr.No.	FNab09101
Alternative Names	FLJ43106 ; LAM ; TSC2 ; TSC4 ; Tuberin ; tuberoussclerosis2 ; Tuberoussclerosis2protein
Background	TSC2, also named as TSC4, FLJ43106 and LAM, acts as a GTPase-activating protein(GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1. In complex with TSC1, TSC2 inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling. TSC2 implicated as a tumor suppressor. It is involved in microtubule-mediated protein transport, but this seems to be due to unregulated mTOR signaling. TSC2 stimulates weakly the intrinsic GTPase activity of the Ras-related proteins RAP1A and RAB5 in vitro. Mutations in TSC2 lead to constitutive activation of RAP1A in tumors. Mutations in either TSC2 or the related TSC1(hamartin) gene cause tuberous sclerosis complex(TSC), an autosomal dominant disorder characterized by development of multiple, widespread non-malignant tumors. The antibody is specific to TSC2.
Categories	Primary Antibodies
Cellular Localization	Cytoplasm, Membrane
Clonality	polyclonal
Description	TSC2, also named as TSC4, FLJ43106 and LAM, acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1. In complex with TSC1, TSC2 inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling. TSC2 implicated as a tumor suppressor. It is involved in microtubule-mediated protein transport, but this seems to be due to unregulated mTOR signaling. TSC2 stimulates weakly the intrinsic GTPase activity of the Ras-related proteins RAP1A and RAB5 in vitro. Mutations in TSC2 lead to constitutive activation of RAP1A in tumors. Mutations in either TSC2 or the related TSC1 (hamartin) gene cause tuberous sclerosis complex (TSC), an autosomal dominant disorder characterized by development of multiple, widespread non-malignant tumors. The antibody is specific to TSC2.
Host	Rabbit
Immunogen	tuberous sclerosis 2
Isotype	IgG
Molecular Weight	200 kDa
Reactivity	Human, Mouse
Regulatory	RUO
Subcellular Location	Cytoplasm, Membrane
Synonyms	FLJ43106, LAM, TSC2, TSC4, Tuberin, tuberous sclerosis 2, Tuberous sclerosis 2 protein

Uniprot	P49815
Gene Id	7249
Research Area	Cell Division and Proliferation
Weight	190kDa

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)

Applications

ELISA, WB, IF, IHC

Description

ELISA ; WB ; IF ; IHC

Dilution

WB	1:200-1:2000
IHC	1:20-1:200
IF	1:10-1:100

Tested Application

WB: 1:200-1:2000; IHC: 1:20-1:200?IF: 1:10-1:100

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SKU	Supplier No.	Size	Your price	Quantity
BHA10809093	FNab09101	100ug	$260		Add to Cart

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