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Home / Primary Antibodies

Tif1 alpha Antibody / Tif1a / Trim24 (F54747)

SKU : BHA17103211

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Mfr.No.	F54747, F54747-0.08ML, F54747-0.4ML
Clonality	Polyclonal
Description	Transcriptional coactivator that interacts with numerous nuclear receptors and coactivators and modulates the transcription of target genes. Interacts with chromatin depending on histone H3 modifications, having the highest affinity for histone H3 that is both unmodified at 'Lys-4' (H3K4me0) and acetylated at 'Lys-23' (H3K23ac) (By similarity). Has E3 protein-ubiquitin ligase activity. Promotes ubiquitination and proteasomal degradation of p53/TP53. Plays a role in the regulation of cell proliferation and apoptosis via its effects on p53/TP53 levels. Up-regulates ligand- dependent transcription activation by AR, GCR/NR3C1, thyroid hormone receptor (TR) and ESR1. Modulates transcription activation by retinoic acid (RA) receptors, such as RARA. Plays a role in regulating retinoic acid-dependent proliferation of hepatocytes. Required for normal transition from proliferating neonatal hepatocytes to quiescent adult hepatocytes.
Formulation	In 1X PBS, pH 7.4, with 0.09% sodium azide
Host	Rabbit
Immunogen Region	A portion of amino acids 789-843 from the mouse protein was used as the immunogen for the Trim24 antibody.
Isotype	Ig
Predicted Reactivity	Mouse
Reactivity	Mouse
Recombinant	No
Subcellular Location	Cytoplasmic, nuclear

Uniprot	Q64127

Format	Purified
Purification	Antigen affinity purified
Storage	Aliquot the Trim24 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Applications	WB, IF, IHC-P
Dilution	Weste blot: 1:500-1:2000, Immunofluorescence: 1:25, Immunohistochemistry (FFPE): 1:25

Product Manual	Data Sheet

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHA17103211-1	F54747-0.08ML	0.08ml	$165		Add to Cart
BHA17103211-2	F54747-0.4ML	0.4ml	$379		Add to Cart

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