Mouse Anti-Rat TASK-1 Potassium Channel Monoclonal IgG2b

Mfr.No.	SMC-473, SMC-473D, SMC-473D-A390, SMC-473D-A488, SMC-473D-A594, SMC-473D-APC, SMC-473D-BI, SMC-473D-FITC, SMC-473D-HRP, SMC-473D-PCP, SMC-473D-RPE, SMC-473S
Immunogen Species	Rat
Alternative Names	Potassium channel subfamily K member 3 Antibody, KCNK3 Antibody, Acid sensitive potassium channel protein TASK 1 Antibody, Cardiac two pore background K(+) channel Antibody, cTBAK 1 Antibody, K2p3.1 Antibody, KCNK9 Antibody, OAT1 Antibody, potassium channel subfamily K member 3 Antibody, rTASK Antibody, TASK 1 Antibody, TBAK1 Antibody, TWIK related acid sensitive K+ channel Antibody, Two pore potassium channel KT3.1 Antibody, Two pore K(+) channel KT3.1 Antibody
Categories	Antibodies
Cellular Localization	Membrane
Certificate Of Analysis	1 ug/ml of SMC-473 was sufficient for detection of TASK1 Potassium Channel in 20 ug of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.
Clonality	Monoclonal
Description	Mouse Anti-Rat TASK1 Potassium Channel Monoclonal IgG2b
Field Of Use	Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
Host	Mouse
Gross Weight (kg)	1.4
Immunogen	Fusion protein amino acids 251-411 (cytoplasmic C-terminus) of rat Acid-sensitive potassium channel protein TASK or TASK1. Mouse: 96% identity (156/161 amino acids identical). Human: 76% identity (163/161 amino acids identical). <30% identity with TASK3., Rattus Norvegicus (Rat)
Immunogen Region	Fusion protein amino acids 251-411 (cytoplasmic C-terminus) of rat Acid-sensitive potassium channel protein TASK or TASK1. Mouse: 96% identity (156/161 amino acids identical). Human: 76% identity (163/161 amino acids identical). <30% identity with TASK3.
Isotype	IgG2b
Launch Date	2013/10/29
Net Weight (g)	0.1
Reactivity	Rat, Mouse, Human
Recombinant	FALSE
Regulatory	RUO
Species	Rattus Norvegicus (Rat)
Species Reactivity Medium	Mouse, Rat, Human

Antigen	KCNK3
Swissprot	O54912
Accession Number	NP_203694.1
Gene Id	29553
Target	KCNK3
Clone No	S374-48
Research Area	Ion Channels, Potassium Channels, Tandem Pore Domain Potassium Channels, Neuroscience

Buffer	PBS pH 7.4, 50% glycerol, 0.1% sodium azide
Concentration	1 mg/ml
Dilutions	WB (1:1000), ICC/IF (1:100); optimal dilutions for assays should be determined by the user.
Purification	Protein G Purified
Scientific Background	K+ channels are divided into three subclasses reflecting the number of transmembrane segments (TMS), which are designated 6TMS, 4TMS and 2TMS. Members of the 4TMS class contain two distinct pore regions and include TWIK, TREK, TRAAK and TASK. TASK channels are highly sensitive to external pH in the physiological range. TASK-1 is expressed in brain and in rat heart, with high levels of expression in the right atrium. TASK-2, mainly expressed in kidney, is localized in cortical distal tubules and collecting ducts, suggesting a role in renal K+ transport. TASK-3 from rat cerebellum shares 54% identity with TASK-1, but less than 30% identity with TASK-2 and other tandem pore K+ channels.
Shipping Temperature	Blue Ice or 4°C
Specificity	Detects ~50kDa. Does not cross-react with TASK3.
Storage	-20ºC
Storage Buffer	PBS pH 7.4, 50% glycerol, 0.1% sodium azide *Storage buffer may change when conjugated
Storage Temperature	-20°C

Applications	IHC, WB, ICC/IF
Description	WB ; IHC ; ICC ; IF
Dilution	WB (1:1000), ICC/IF (1:100); optimal dilutions for assays should be determined by the user.

Product Manual	SDS
SDS

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Combination SKU	Supplier No.	Conjugate	Size	Your price
BHA11904856-1	SMC-473D	Unconjugated	100 ug	$337	Add to Cart
BHA11904856-2	SMC-473D-A390	ATTO 390	100 ug	$392	Add to Cart
BHA11904856-3	SMC-473D-A488	ATTO 488	100 ug	$391	Add to Cart
BHA11904856-4	SMC-473D-A594	ATTO 594	100 ug	$391	Add to Cart
BHA11904856-5	SMC-473D-APC	APC	100 ug	$390	Add to Cart
BHA11904856-6	SMC-473D-BI	Biotin	100 ug	$386	Add to Cart
BHA11904856-7	SMC-473D-FITC	FITC	100 ug	$381	Add to Cart
BHA11904856-8	SMC-473D-HRP	HRP	100 ug	$377	Add to Cart
BHA11904856-9	SMC-473D-PCP	PerCP	100 ug	$390	Add to Cart
BHA11904856-10	SMC-473D-RPE	RPE	100 ug	$388	Add to Cart
BHA11904856-11	SMC-473S	Unconjugated	12 ug	$45	Add to Cart

TASK-1 Antibody, Clone N374/48 (SMC-473)

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