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Home / Primary Antibodies

TAP2 Antibody / ABCB3 (N-Terminal Region) (F54197)

SKU : BHA17102709

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NSJ Bioreagents

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Mfr.No.	F54197, F54197-0.05ML, F54197-0.2ML
Clonality	Polyclonal
Description	Involved in the transport of antigens from the cytoplasm to the endoplasmic reticulum for association with MHC class I molecules. Also acts as a molecular scaffold for the final stage of MHC class I folding, namely the binding of peptide. Nascent MHC class I molecules associate with TAP via tapasin. Inhibited by the covalent attachment of herpes simplex virus ICP47 protein, which blocks the peptide-binding site of TAP. Inhibited by human cytomegalovirus US6 glycoprotein, which binds to the lumenal side of the TAP complex and inhibits peptide translocation by specifically blocking ATP-binding to TAP1 and prevents the conformational rearrangement of TAP induced by peptide binding. Inhibited by human adenovirus E3-19K glycoprotein, which binds the TAP complex and acts as a tapasin inhibitor, preventing MHC class I/TAP association.
Formulation	In 1X PBS, pH 7.4, with 0.09% sodium azide
Host	Rabbit
Immunogen Region	A portion of amino acids 100-134 from human TAP2 was used as the immunogen for the TAP2 antibody.
Isotype	Ig
Predicted Reactivity	Human
Reactivity	Human
Recombinant	No

Uniprot	Q03519

Format	Antigen affinity purified
Purification	Antigen affinity
Storage	Aliquot the TAP2 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Applications	WB
Dilution	WB: 1:1000-1:2000

Product Manual	Data Sheet

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHA17102709-1	F54197-0.05ML	0.05ml	$165		Add to Cart
BHA17102709-2	F54197-0.2ML	0.2ml	$379		Add to Cart

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