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Home / Primary Antibodies

Stat3 Polyclonal Antibody

SKU : BHA13715256

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Abbkine Scientific Co., Ltd.

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Mfr.No.	ABP0124
Alternative Names	STAT3; APRF; Signal transducer and activator of transcription 3; Acute-phase response factor
Background	Signal transducer and activator of transcription 3 encoded by STAT3 is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Mutations in this gene are associated with infantile-onset multisystem autoimmune disease and hyper-immunoglobulin E syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
Clonality	Polyclonal
Description	Rabbit Anti-Stat3 Polyclonal Antibody
Formulation	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen, Liquid solution
Host	Rabbit
Immunogen	Synthesized peptide derived from human Stat3 around the non-phosphorylation site of Y705
Immunogen Region	Synthesized peptide derived from human Stat3 around the non-phosphorylation site of Y705
Isotype	Rabbit IgG
Molecular Weight	88 KD
Others	Stat3 Polyclonal Antibody detects endogenous levels of Stat3 protein.
Precautions	The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.
Reactivity	Human, Mouse, Rat
Tag	Signal transducer and activator of transcription 3
Note	Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), IF (1:50-1:200), IHC-P (1:100-1:300), ELISA (1:5000). Not yet tested in other applications.

Accession Number	P40763
Gene Id	6774, 6774

Concentration	1 mg/ml, 1 mg/ml
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen, The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
Storage Buffer	PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Storage Instructions	Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Applications	WB, IF, IHC-P, ELISA

Product Manual	Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHA13715256	ABP0124	100 uL	$229		Add to Cart

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