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Home / Primary Antibodies / Polyclonal Antibodies

SH3BP1 Antibody (CSB-PA23069A0Rb)

SKU : BHA10534415

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA23069A0Rb
Alternative Names	SH3 domain-binding protein 1, SH3BP1
Categories	Primary Antibodies
Clonality	polyclonal
Description	Binds differentially to the SH3 domains of certain proteins of signal transduction pathways. This protein binds preferentially to the ABL1 proto-oncogene, SRC and GRB2. Shows GAP activity for Rac-related proteins but not for Rho- or Ras-related proteins. It inhibits PDGF-induced membrane ruffling mediated by Rac (By similarity).
Host	Rabbit
Immunogen	Recombinant Human SH3 domain-binding protein 1 protein (161-266AA)
Isotype	IgG
Raised In	Rabbit
Reactivity	Human
Regulatory	RUO
Relevance	Binds differentially to the SH3 domains of certain proteins of signal transduction pathways. This protein binds preferentially to the ABL1 proto-oncogene, SRC and GRB2. Shows GAP activity for Rac-related proteins but not for Rho- or Ras-related proteins. It inhibits PDGF-induced membrane ruffling mediated by Rac (By similarity).
Species	Homo Sapiens (Human)
Subcellular Location	Cell projection, Cell junction, tight junction, Cell junction, adherens junction, Cell projection, phagocytic cup, Nucleus, Cytoplasm, cytosol

Antigen	SH3BP1
Uniprot	Q9Y3L3
Database Links	HGNC:10824 OMIM:617368 KEGG:hsa:23616 STRING:9606.ENSP00000350018 UniGene:Hs.601143
Function	GTPase activating protein (GAP) which specifically converts GTP-bound Rho-type GTPases including RAC1 and CDC42 in their inactive GDP-bound form. By specifically inactivating RAC1 at the leading edge of migrating cells, it regulates the spatiotemporal organization of cell protrusions which is important for proper cell migration
Research Area	Signal Transduction

Buffer	Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form	Liquid
Format	Liquid
Purification	>95%, Protein G purified
Purity	>95%, Protein G purified
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Storage Buffer	Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Applications

ELISA, IHC

Description

ELISA ; IHC, IHC ; ELISA

Dilution

IHC	1:200-1:500

Tested Application

ELISA, IHC; Recommended dilution: IHC:1:200-1:500

Datasheet
ELISA Protocol
Immunohistochemistry (IHC) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10534415	CSB-PA23069A0Rb	50ug	$166		Add to Cart
BHA10534415	CSB-PA23069A0Rb	100ug	$299		Add to Cart

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