CDK4 controls cell growth during the cell cycle G1 phase. It is reported that D-type cyclin upregulates Cdk4 activity, whereas binding to the Cdk inhibitor p16 downregulates Cdk4 activity. Cyclin D-CDK4 complexes integrates various mitogenenic and antimitogenic signals and serves as sensitive and specific for atypical lipomatous tumor / well differentiated liposarcoma or dedifferentiated liposarcoma.
Formulation
Tris Buffer, pH 7.3 - 7.7, with 1% BSA and <0.1% Sodium Azide
Immunogen
Recombinant Protein
Immunogen Region
Recombinant Protein
Isotype
IgG
Raised In
Rabbit
Shipping Condition
Ice packs
Species Reactivity
Human
Specificity
CDK4
Note
1:50-1:200
Clone No
IHC077
Purity
Purified
Storage
This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20° C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.