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Home / Primary Antibodies / Polyclonal Antibodies

Rabbit Anti-Rat SOD1 (Cu/Zn) Polyclonal (SPC-115)

BHA11906463
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+1 866.986.9598
Email
orders@biohippo.com
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Antigen SOD1
Swissprot P07632
Accession Number NP_058746.1
Gene Id 24786
Target SOD1
Research Area Cancer, Oxidative Stress, Cell Signaling, Chaperone Proteins, Neurodegeneration, ALS Disease, Neuroscience, Protein Trafficking
Buffer PBS pH7.0, 50% glycerol, 0.09% sodium azide
Concentration 1 mg/ml
Dilutions WB (1:2000), ICC/IF (1:120); optimal dilutions for assays should be determined by the user.
Purification Protein A Purified
Scientific Background Superoxide dismutase (SOD) is an endogenously produced intracellular enzyme present in almost every cell in the body (3). It works by catalyzing the dismutation of the superoxide radical O2? to O2 and H2O2, which are then metabolized to H2O and O2 by catalase and glutathione peroxidase (2,5). In general, SODs play a major role in antioxidant defense mechanisms (4).
There are two main types of SOD in mammalian cells. One form (SOD1) contains Cu and Zn ions as a homodimer and exists in the cytoplasm. The two subunits of 16 kDa each are linked by two cysteines forming an intra-subunit disulphide bridge (3). The second form (SOD2) is a manganese containing enzyme and resides in the mitochondrial matrix. It is a homotetramer of 80 kDa. The third form (SOD3 or EC-SOD) is like SOD1 in that it contains Cu and Zn ions, however it is distinct in that it is a homotetramer, with a mass of 30 kDA and it exists only in the extra-cellular space (7). SOD3 can also be distinguished by its heparin-binding capacity (1).
Shipping Temperature Blue Ice or 4°C
Specificity Detects ~23kDa (human) and ~19kDa (other species).
Storage -20ºC
Storage Buffer PBS pH7.0, 50% glycerol, 0.09% sodium azide *Storage buffer may change when conjugated
Storage Temperature -20°C
Applications ELISA, IHC, IP, WB, ICC/IF
Description WB ; IHC ; ICC ; IF ; IP ; ELISA
Dilution WB (1:2000), ICC/IF (1:120); optimal dilutions for assays should be determined by the user.
Product Manual SDS
SDS
Reference 1. Adachi T., et al. (1992). Clin. Chim. Acta. 212: 89-102.

2. Barrister J.V., et al. (1987). Crit. Rev. Biochem. 22:111-180.

3. Furukawa Y., O'Halloran T. (2006). Antioxidants & Redo Signaling. Vol 8, No 5,6.

4. Gao B., et al. (2003). Am J Physiol Lung Cell Mol Physiol 284: L917-L925.

5. Hassan H.M. (1988). Free Radical Biol. Med. 5: 377-385.

6. Kurobe N., et al. (1990) Biomedical Research. 11: 187-194

7. Wispe J.R., et al. (1989) BBA. 994: 30-36.

8. Xiao-Hong Liu., et al. (1993) Brain Research. 625: 29-37.
Combination SKU Supplier No. Conjugate Size Your price Quantity
BHA11906463-1 SPC-115D Unconjugated 100 ug $352
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BHA11906463-2 SPC-115D-A390 ATTO 390 100 ug $407
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BHA11906463-3 SPC-115D-A488 ATTO 488 100 ug $406
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BHA11906463-4 SPC-115D-A594 ATTO 594 100 ug $406
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BHA11906463-5 SPC-115D-APC APC 100 ug $405
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BHA11906463-6 SPC-115D-BI Biotin 100 ug $402
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BHA11906463-7 SPC-115D-FITC FITC 100 ug $397
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BHA11906463-8 SPC-115D-HRP HRP 100 ug $393
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BHA11906463-9 SPC-115D-PCP PerCP 100 ug $405
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BHA11906463-10 SPC-115D-RPE RPE 100 ug $403
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BHA11906463-11 SPC-115S Unconjugated 12 ug $45
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